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NCT04110574 Clinical Trial

Computed Tomography Evaluation of Urinary Stones Densities Compared to in Vitro Analysis of Its Chemical Composition

Urinary Calculi Clinical Trial

Official title:
Computed Tomography Evaluation of Urinary Stones Densities Compared to in Vitro Analysis of Its Chemical Composition

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT04110574
Other study ID # CT of urinary stones densities
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date March 30, 2020
Est. completion date October 30, 2022

Study information
Verified date February 2020
Source Assiut University
Contact Somia Usama, Master
Phone 01060101215
Email somiaumrm@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The ability to predict stone composition, which influences patient treatment, depends on the accurate measurement of CT attenuation of stones. We will study the effects of stone composition, stone size, and scan collimation width on the measurement of attenuation in vitro.

Description:

Recently, the use of noncontrast spiral computerized tomography (NCCT) has gained widespread acceptance in the evaluation of urinary stone patients. It has long been used clinically to evaluate the causes of radiolucent filling defects using Hounsfield units (HU) to distinguish calculi from tumor or blood clots, and to identify nonurologic causes of flank pain (Smith R etal ). Urinary stones have a significantly higher CT attenuation than the surrounding soft tissues and are virtually always visible on NCCT. Knowing the composition of a urinary calculus is frequently a key factor in determining its most appropriate management. Should the urine be alkalinized? Will the stone be amenable to extracorporeal shock wave lithotripsy (ESWL), or should ureteroscopy or percutaneous lithotripsy be attempted? Different techniques have been used to assist in determining the correct chemical composition of calculi. Urine pH, urinary crystals, prior stone history and the presence of urea-splitting organisms (Ramakumar S,etal). Several in vitro studies have suggested that NCCT can demonstrate measured differences in radiodensity among different urinary stones (Mitchenson HD etal,).With these clinical problems in mind, we sought to determine whether the composition of urinary calculi could be predicted by their CT characteristics in an attempt to find out the best technique for distinguishing the various stones compositions, provided that it is clinically practical and would not require repeated imaging of the patients.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 100
Est. completion date October 30, 2022
Est. primary completion date September 1, 2022
Accepts healthy volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Any Age will be included .

- Patient with suspected or known urinary stone disease.

- Eligible for doing NCCT.

- Giving written consent to participate

Exclusion Criteria:

- Patient with classical NCCT contraindication like morbid obesity and pregnancy .

- Patients with urinary stones will be treated by ESWL

- Refusal participation .

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Outcome
Type Measure Description Time frame Safety issue
Primary comparison of CT densities of urinary stones with its chemical composition determination whether the composition of urinary calculi could be predicted by their CT characteristics in an attempt to find out the best technique for distinguishing the various stones compositions . Baseline
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