Clostridium Histolyticum Collagenase Injection for Urethral Disease

Clinical Trial Description

This is an open-label, pilot study to explore the efficacy of clostridium histolyticum collagenase (XIAFLEX®) in treating urethral strictures. Subjects will be followed for 2 years from the initial drug treatment. ;

Study Design

See also
Status	Clinical Trial	Phase
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Recruiting	`NCT05519566` - The Accuracy of Pulsed Fluoroscopy Retrograde Urethrogram Vs the Traditional Retrograde Urethrogram In Diagnosing Urethral Stricture	N/A
Recruiting	`NCT04071925` - 9000 URETHRA STUDY: a Study About Urethroplasty for Urethral Stricture Disease
Terminated	`NCT02551783` - Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft	N/A
Active, not recruiting	`NCT03270384` - Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease	N/A
Not yet recruiting	`NCT03258658` - Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures	Phase 1
Completed	`NCT03973619` - Urethral Stricture: A Comparison Between Jugal or Labial Graft Urethroplasty	N/A
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Withdrawn	`NCT03851952` - Re-Establishing Flow Via Drug Coated Balloon for the Treatment of Urethral Stricture Disease - Registry Study	N/A
Recruiting	`NCT04161365` - Feasibility and Therapeutic Potential of Free Fat Grafts in the Treatment of Urethral Strictures	N/A
Not yet recruiting	`NCT06384066` - Mobile Health Application to Improve Patient Satisfaction After Urethroplasty	N/A
Completed	`NCT03859024` - Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty	Phase 4
Active, not recruiting	`NCT03499964` - ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease	N/A
Terminated	`NCT02634619` - A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty	N/A
Not yet recruiting	`NCT00918528` - Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy	Phase 1/Phase 2
Not yet recruiting	`NCT06064968` - Effectiveness of Intermittent Bladder Catheterization (IBC) in Reducing Recurrence of Urethral Stricture	N/A
Completed	`NCT05078788` - Holmium Laser Uretherotomy in Combination With Intralesional Steroids in Bulbar Uretheral Stricture	N/A
Enrolling by invitation	`NCT03205670` - Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers	Early Phase 1
Recruiting	`NCT05464290` - The Nanofat Regenerative Surgery for Management of Genital Lichen Sclerosus in Male and Female Patients	N/A

NCT number	NCT02948842
Study type	Interventional
Source	University of South Florida
Contact
Status	Completed
Phase	Phase 2
Start date	May 22, 2020
Completion date	April 12, 2023

Clostridium Histolyticum Collagenase Injection for Urethral Disease

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms