Ureteral Calculi Clinical Trial
Official title:
Medical Expulsive Therapy of Single Distal Ureteral Stones. A Randomised, Double-blind and Placebo-controlled Study
Current therapeutic options for ureteral stones include active intervention as well as
conservative "watch and wait" approaches. Endoscopic treatment of ureteral stones has a high
success rate and reliably results in immediate stone removal However, surgical as well as
anaesthetic risks are not negligible and serious complications are possible. For many
patients, a conservative treatment is an appealing option. Watchful waiting, however, not
always results in stone clearance and may be associated with recurrent renal colics.
The therapeutic potential of alpha-blockers for ureteral stone disease has been investigated
prompted by the detection of alpha-receptors in ureteral smooth muscle cells. Blocking of
such receptors, which are predominantly located in the distal part of the ureter results in
relaxation of the ureteral wall and modulation of peristaltic activity. This mechanism has
been proposed to facilitate stone passage for ureteral calculi.
Numerous clinical trials have revealed a significant improvement of the stone expulsion rate
using the alpha-blocker tamsulosin. Most of these studies were randomised but none were
performed in a double-blind and placebo-controlled fashion. Therefore, the objective of this
trial was to evaluate the efficacy of medical expulsive therapy with tamsulosin in a
randomised, double-blind, placebo-controlled setting.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05100017 -
Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure
|
N/A | |
Recruiting |
NCT03692715 -
Antibiotic Prophylaxis Before Shock Wave Lithotripsy
|
Phase 4 | |
Recruiting |
NCT01450566 -
Intraureteral Lidocaine for Post-Ureteroscopy Pain
|
N/A | |
Completed |
NCT00177086 -
Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi
|
Phase 3 | |
Completed |
NCT02577146 -
The Predictive Value of Ureteral Jet Assessment With Ultrasound in Patients Presenting With Acute Renal Colic
|
N/A | |
Completed |
NCT00517205 -
Study on 'The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcomes of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter'
|
N/A | |
Completed |
NCT06105827 -
Clinical Study of Ningmitai Capsule on Promoting the Passage of Residual Fragments After Ureteroscopic Lithotripsy
|
Phase 4 | |
Completed |
NCT03888144 -
Study of Ketorolac Versus Opioid for Pain After Endoscopy
|
Phase 4 | |
Not yet recruiting |
NCT04606758 -
Fluoroscopic Guided vs US-guided Percutaneous Nephrolithotripsy for the Treatment of Stone Disease
|
N/A | |
Not yet recruiting |
NCT01008267 -
Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia.
|
N/A | |
Completed |
NCT04069338 -
Comparison of Lithotripsy Urolithiasis Machines
|
N/A | |
Recruiting |
NCT04069013 -
Standard vs Mini-PCNL for the Treatment of Stone Disease
|
N/A | |
Withdrawn |
NCT00304317 -
Celecoxib (Celebrex) in the Management of Acute Renal Colic
|
Phase 4 | |
Recruiting |
NCT01167062 -
Efficacy of Tamsulosin Oral-controlled Absorption System (OCAS) in the Treatment of Distal Ureteral Stones
|
Phase 4 | |
Completed |
NCT01144949 -
Study of Silodosin to Facilitate Passage of Urinary Stones
|
Phase 2 | |
Terminated |
NCT03614052 -
Tamsulosin as Adjuvant Treatment Prior to Endoscopic Ureterolithotomy
|
Phase 4 | |
Completed |
NCT03344120 -
Symptoms Comparison: Suture-stent vs Conventional Double-J Stents After Ureterorenoscopy. A Prospective Randomized Trial
|
N/A | |
Completed |
NCT05153629 -
Noninvasive Electrical Stimulator as a Pain Control Treatment Post-ureteroscopy
|
N/A | |
Recruiting |
NCT05739812 -
The Efficacy and Safety of Chinese Domestic Surgical Robot System in Urological Telesurgery
|
N/A | |
Completed |
NCT01542593 -
Evaluating Ureteral Length Using Computed Tomography (CT)
|
N/A |