Univentricular Heart Clinical Trial
Official title:
The Lymphatic Morphology and Function of Fontan-Kreutzer Operated Patients
The lymphatics regulate the interstitial fluid by removing excessive fluid. It represents an
extremely important step in the prevention of edema. The Fontan-Kreutzer procedure has
revolutionized the treatment of univentricular hearts. However, it is associated with severe
complications such as protein-losing enteropathy (PLE) and peripheral edema that may involve
the lymphatic circulation.
Our hypothesis is that patients with a univentricular circulation have a reduced
functionality of the lymphatic vasculature, which predisposes them to developing
complications such as edema and PLE.
The functional state of lymphatics is investigated using near infrared fluorescence imaging,
NIRF. The anatomy is described using non-contrast MRI and the capillary filtration rate is
measured using plethysmography.
Background:
The lymphatics regulate the interstitial fluid by removing excessive fluid. It represents an
extremely important step in the prevention of edema. The Fontan-Kreutzer procedure has
revolutionized the treatment of univentricular hearts. However, it is associated with severe
complications such as protein-losing enteropathy (PLE) and peripheral edema that may involve
the lymphatic circulation.
Hypothesis:
Patients with a univentricular circulation have a reduced functionality of the lymphatic
vasculature, which predisposes them to developing complications such as edema and PLE.
Material and Methods:
The functional state of lymphatics is investigated using near infrared fluorescence imaging,
NIRF. The anatomy is described using non-contrast MRI and the capillary filtration rate is
measured using plethysmography. The study population is patients with Fontan-Kreutzer
circulation operated at Aarhus University hospital. Exclusion criteria is BMI>30 and age
(years) < 18. The Fontan-Kreutzer group will be compared with an age, gender and weight
matched control group of healthy volunteers.
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