Under-vaccinated Clinical Trial
— MOVEOfficial title:
Missed Opportunities for Vaccine Equity
| Verified date | October 2022 |
| Source | Johns Hopkins Bloomberg School of Public Health |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
Despite the overwhelming impact of vaccines on child health and the tremendous progress in vaccine coverage globally, challenges of vaccine inequities persist. Missed opportunities for vaccination (MOV) is defined as any contact with health services by an individual who is eligible for vaccination which does not result in the recommended vaccines being given. This is common in several countries, and it presents a window of opportunity to provide vaccine services to those vulnerable children accessing healthcare facilities. The overall purpose of this project is to reduce missed opportunities for vaccinations by targeting hospitalized children who are vulnerable to poor health outcomes, but who are also within easy access of the healthcare system. The research team proposes implementing the Missed Opportunities for Vaccination Equity (MOVE), an intervention to improve timeliness and coverage of vaccination, and increase demand for vaccination services, through a combination of sensitization of children's caregivers and health workers, manual vaccination data capture in the ward, and re-purposed vaccination resources. The strategy engages key stakeholders in the design of the intervention through a co-creation workshop; their involvement in the design and execution of the intervention will improve sustainability in the long-term. This intervention builds on existing healthcare systems, and, when scaled up, can target inequities in vaccination coverage in the general population, without placing additional strain on the healthcare system in terms of workforce or financial resources.
| Status | Completed |
| Enrollment | 900 |
| Est. completion date | September 16, 2021 |
| Est. primary completion date | September 16, 2021 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 0 Months to 23 Months |
| Eligibility | Inclusion Criteria: - Children between the ages 0-23 months who are admitted into the emergency or inpatient unit of the hospital - Caregiver has access to the child's vaccination card or has direct knowledge of the child's vaccination history - Caregiver willing to provide informed consent for the study Exclusion Criteria: - Health condition that precludes the use of vaccines such as a primary or secondary immune deficiency, such as HIV, malignancy requiring chemotherapy, or ongoing steroid therapy - Allergies or contraindications to any vaccine (or component thereof) in the national schedule |
| Country | Name | City | State |
|---|---|---|---|
| India | Post Graduate Institute of Medical Education and Research, India (PGIMER) | Chandigarh | |
| Nigeria | Aminu Kano Teaching Hospital | Kano | Kano State |
| Lead Sponsor | Collaborator |
|---|---|
| Johns Hopkins Bloomberg School of Public Health | Aminu Kano Teaching Hospital, Postgraduate Institute of Medical Education and Research, Chandigarh |
India, Nigeria,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Proportion of Children Fully Vaccinated Hospital Discharge | The number fully vaccinated at admission + number given catch-up vaccination while in hospital, and up to the date at discharge / the number of all enrolled children. This outcome measures the desired outcome of full vaccination coverage among children who pass through in-patient health facilities. This is the main outcome of interest and will be compared in the pre-intervention and post-intervention phases. | time of admission to discharge (about 1-2 weeks) | |
| Primary | Partially Vaccinated or Un-vaccinated Children at Admission | This is the proportion of those children who are under-vaccinated at hospital admission. | time of admission to discharge (about 1-2 weeks) | |
| Primary | Proportion of Under-Vaccinated children Deemed "Missed Opportunities of Vaccination" | The number of eligible children who do not receive their due catch-up vaccines prior to hospital discharge / the number of children identified as under-vaccinated at hospital admission. | time of admission to discharge (about 1-2 weeks) | |
| Primary | Proportion of all Enrolled Children at Admission Given Vaccination Advice | The number of all enrolled children at admission who get vaccination-related advice and/or referrals during the hospital stay / the number of all enrolled children participating in the study. | time of admission to discharge (about 1-2 weeks) | |
| Primary | Proportion of Incompletely Vaccinated Children Caught up After Discharge | The number of incompletely vaccinated children at hospital discharge who get caught up on vaccinations within 1-4 weeks of hospital discharge / the number of children identified as under-vaccinated at hospital discharge. | time of admission (about 1-2 weeks) to 1 month post discharge |