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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04057027
Other study ID # KAEK/2019.02.36
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date September 15, 2019
Est. completion date October 1, 2020

Study information

Verified date May 2020
Source Kanuni Sultan Suleyman Training and Research Hospital
Contact Seda Yilmaz Semerci
Phone 05337180683
Email sedayilmazsemerci@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants.

In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.


Recruitment information / eligibility

Status Recruiting
Enrollment 90
Est. completion date October 1, 2020
Est. primary completion date September 5, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A to 30 Minutes
Eligibility Inclusion Criteria:

- Infants born under 32 weeks of gestation

- Accepted to participate with informed consent

- History of healthy pregnancy

- Infants born and will be followed up at the study hospital

Exclusion Criteria:

- Congenital abnormalities

- Chromosomal abnormalities

- Declined to participate

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
Delayed umbilical cord clamping
During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.
Cord Milking
Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times.

Locations

Country Name City State
Turkey Istanbul Kanuni Sultan Suleyman Training and Research Hospital Istanbul

Sponsors (2)

Lead Sponsor Collaborator
Kanuni Sultan Suleyman Training and Research Hospital Turkish Neonatology Society

Country where clinical trial is conducted

Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary Concentration of Stem cells Determining the quantity of endogenous stem cells transmitted through the umbilical cord to the infant after different types of cord clamping. 6 months
Secondary Number of Participants with Neonatal Morbidities Recording newborn morbidities such as intraventricular hemorrhage , necrotizing enterocolitis, bronchopulmonary dysplasia , retinopathy of prematurity which are detected in the study population. 6 months