Ulcer Clinical Trial
Official title:
Effect of Plasma Derived Exosomes on Intractable Cutaneous Wound Healing: Prospective Trial
This study is an open prospective clinical trial. The objective is to evaluate the effect of autologous exosomes rich plasma on cutaneous wound healing. The participants are patients with intractable cutaneous ulcers (e.g. rheumatic disease, peripheral arterial disease, chronic venous insufficiency, decubitus or burns). The participants will be treated autologous exosomes rich plasma every day for 28 days. The cutaneous wound healing will be evaluated by the length, width and depth of the wound.
Exosomes are small vesicles 0.03-0.1 μm in size, which are shed from most cell types into the
extracellular space via intracellular endocytosis. They are found abundantly in body fluids
such as blood. They consist of lipid bilayer so that their structure is stable. They can be
preserved for 2 weeks at 4℃. They contain proteins, lipids and nucleic acids including coding
or non-coding RNA. Resent studies have revealed that exosomes have an important role in
cell-to-cell communication.
The investigators found that serum exosome levels were significantly decreased in scleroderma
patients with vascular involvements such as cutaneous ulcers and/or pitting scars compared to
in normal subjects. The investigators also elucidated that serum-derived exosomes accelerated
cutaneous wound healing in BALB/c mice. Exosome supplementation to cutaneous ulcers seems to
have significant therapeutic value.
The objective of present study is to evaluate the effect of exosomes derived from plasma on
intractable cutaneous ulcers (e.g. rheumatic disease, peripheral arterial disease, chronic
venous insufficiency, decubitus or burns).
Autologous exosomes are obtained from the participants' own plasma. The duration of study is
28days. The cutaneous wound healing will be evaluated at day1, day2, day7, day14, day 21 day
28.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02838251 -
Effects of Compression in Mixed Ulcers
|
N/A | |
| Recruiting |
NCT00926809 -
H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection
|
Phase 4 | |
| Completed |
NCT00633035 -
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit
|
Phase 4 | |
| Completed |
NCT00402727 -
Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection
|
Phase 3 | |
| Completed |
NCT06464250 -
The Effect of Bundle Approach on Foot Care Behaviors and Diabetic Wound Healing in Patients
|
N/A | |
| Not yet recruiting |
NCT03250533 -
Analysis of the Effects of LED Phototherapy and Electrical Stimulation in the Healing of Diabetic Ulcers
|
N/A | |
| Terminated |
NCT01657318 -
Olivamine-containing Products in the Management of Patients With Nonhealing Lower Extremity Ulcers
|
||
| Completed |
NCT02535481 -
Epidermal Grafting in Wound Healing
|
N/A | |
| Withdrawn |
NCT01215058 -
Gastroprotective Agent Compliance in Patients at Risk Suffering From a Gastrointestinal(GI) Ulcer
|
N/A | |
| Recruiting |
NCT04210089 -
Total Contact Soft Cast in Diabetic Foot Ulcers
|
N/A | |
| Completed |
NCT04573959 -
Validation of CapsoVision CapsoCam® SV-3 Capsule Endoscopy System
|
N/A | |
| Recruiting |
NCT03347812 -
Clinical Study for Evaluating the Safety and Efficacy of Total Endovascular Aortic Arch Repair
|
N/A | |
| Active, not recruiting |
NCT02973893 -
Study of VF001-DP in Patients With Chronic Venous Leg Ulcers
|
Phase 2 | |
| Terminated |
NCT01853384 -
Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers
|
Phase 3 | |
| Completed |
NCT00221143 -
Stem Cell Study for Patients With Leg Ulcer/Gangrene
|
Phase 1/Phase 2 | |
| Completed |
NCT00158483 -
Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212)
|
Phase 2 | |
| Completed |
NCT00660049 -
Feasibility Study of a Novel Device for Chronic Wounds
|
N/A | |
| Completed |
NCT00450216 -
Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment
|
Phase 3 | |
| Completed |
NCT00164424 -
Episodic Acyclovir Therapy for Genital Ulcers
|
Phase 2/Phase 3 | |
| Completed |
NCT02733978 -
Ozone Therapy in the Treatment of Digital Ulcers in Patients With Systemic Sclerosis
|
N/A |