Type I Hypersensitivity Clinical Trial
Official title:
Follow-up Study to Evaluate the Sustained Clinical Efficacy of Ragweed MATA MPL (Allergy Therapeutics®) in Patients With Ragweed-induced Seasonal Allergic Rhinitis Upon Re-exposure to Ragweed Pollen in an Environmental Exposure Chamber (EEC) Model, Approximately One Year After Pre-seasonal Treatment in 2005
Ragweed MATAMPL has been developed to provide pre-seasonal specific immunotherapy for patients with hypersensitivity to ragweed pollen (hay fever). This novel formulation is designed to provide a vaccine that will be efficacious with only four escalating dose injections administered before the start of the pollen season. In this Follow-up Study the Efficacy will be assessed by exposing allergic subjects to Ragweed pollen in an environmental exposure chamber EEC. Patient symptomatic response to pollen and patient quality of life in the EEC will be determined. Patients who previously completed two EEC portions of study Ragweed MATAMPL 204 and who had been treated with either Ragweed MATA MPL or Placebo before the 2005 ragweed season will be enrolled.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00133146 -
Assessment of the Contribution of Monophosphoryl Lipid A (MPL) to a Grass Pollen Allergy Vaccine
|
Phase 2 | |
| Completed |
NCT00133159 -
Different Doses of Tyrosine Adsorbed Grass Pollen Allergoid With Monophosphoryl Lipid A (MPL) in Patients Sensitized to Grass Pollen
|
Phase 2 | |
| Terminated |
NCT00387478 -
Investigation of Efficacy and Safety of Tree MATAMPL,Tree MATA, and Placebo in Patients With Birch-Induced Seasonal Allergic Rhinitis
|
Phase 2 | |
| Completed |
NCT00414141 -
Efficacy and Safety/Tolerability of Grass MATA MPL
|
Phase 3 | |
| Completed |
NCT00258635 -
Investigation of Safety+Efficacy of Different Doses of RagweedMATAMPL;Assessment of Residual Allergenicity Using Skin Prick Test
|
Phase 2 | |
| Completed |
NCT00110786 -
Investigation of Efficacy and Safety of Ragweed MATAMPL, Pollinex-R and Placebo in Patients With Ragweed Allergy
|
Phase 2 | |
| Withdrawn |
NCT00109759 -
Evaluation of Safety and Tolerability of Tyrosine Adsorbed Ragweed Pollen Allergoid With MPL (Monophosphoryl Lipid A)
|
Phase 1 | |
| Completed |
NCT00423787 -
Efficacy and Safety/Tolerability of Ragweed MATA MPL
|
Phase 3 | |
| Completed |
NCT00104390 -
Assessment of Residual Allergenicity of Grass/Rye Pollen Allergoid Using Skin Prick Testing
|
Phase 1 | |
| Completed |
NCT00104377 -
Induction of Immunogenicity With Different Doses of Grass MATA in Subjects Allergic to Grass and Rye Pollen
|
Phase 2 | |
| Completed |
NCT00116285 -
Assessment of Residual Allergenicity of Ragweed Pollen Allergoid With Monophosphoryl Lipid A (MPL) Using Skin Prick Testing
|
Phase 1 | |
| Completed |
NCT00118612 -
Different Doses of Tyrosine Adsorbed Tree Pollen Allergoid With Monophosphoryl Lipid A (MPL) in Patients Sensitized to Tree Pollen
|
Phase 2 | |
| Completed |
NCT00118625 -
Assessment of the Contribution of Monophosphoryl Lipid A (MPL) to a Tree Pollen Allergy Vaccine
|
Phase 2 | |
| Completed |
NCT00113750 -
Induction of Immunogenicity With Different Doses of TreeMATA in Subjects Allergic to Tree Pollen
|
Phase 2 | |
| Completed |
NCT00241410 -
Safety, Immunological Effect and Efficacy of the Combined Application of MPL and Grass Pollen Allergen
|
Phase 1 | |
| Completed |
NCT00107705 -
Assessment of Residual Allergenicity of Tree (Birch, Hazel, and Alder) Pollen Allergoid Using Skin Prick Testing
|
Phase 1 |