Type 1 Diabetes Clinical Trial
Official title:
Evaluation of the Use of 11C-5-HTP PET to Calculate βCell Mass in Clinical Islet Transplantation (DAIT CIT-09)
In people with type I diabetes, the insulin producing cells in the pancreas have been
destroyed. Presently one can only evaluate the function of the graft through laboratory
tests, blood sugars and the insulin requirements. The mass of the insulin producing cells
and their location are not known. The possibility to study the mass of insulin producing
cells is of importance when developing new treatment regimes, in order to evaluate their
efficacy on this parameter.
The researchers in this study are aiming to develop methods to measure the mass of insulin
producing cells. A method (positron emission tomography, PET) previously used for the
diagnosis of tumors of insulin producing cells may also be used to measure the amount of
insulin producing cells in patients with type I diabetes. They plan to evaluate participants
with type 1 diabetes that have undergone islet transplantation, to evaluate if PET can be
used to measure the beta cell mass after islet transplantation.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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