Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children — CCM  

Type 1 Diabetes Clinical Trial

Official title: Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children

Status Completed

Clinical Trial Summary

The overall aim of this study is to confirm the utility of corneal confocal microscopy (CCM) as a new technique to rapidly and non-invasively assess diabetic neuropathy (DN) in children. This study will be divided into two phases: Phase 1 will be a cross-sectional study of children with type 1 diabetes and normal controls, while phase 2 will be a longitudinal assessment of a subgroup of children with type 1 diabetes recruited during Phase 1.

Clinical Trial Description

In phase 1: To compare corneal nerve density (CND), length (CNL), and branching (CBD) by CCM between

1. children with type 1 diabetes for 5 years or more to children without diabetes;

2. children with type 1 diabetes with and without evidence of diabetic neuropathy;

3. to examine the relationship between CND, CNL & CBD and known risk factors of diabetic neuropathy

In phase 2:

1. to examine for changes in corneal nerve morphology two years after the initial CCM exam.

2. to describe the evolution of diabetic neuropathy based on clinical symptoms, neurological deficits, and other tests of nerve dysfunction.

3. to assess if changes in corneal nerve morphology correlate with changes in nerve conduction velocity and autonomic testing.

4. To examine the risk factors associated with progression of diabetic neuropathy in our pediatric population. ;

Related Conditions & MeSH terms

• Diabetic Neuropathies
• Neuropathy
• Peripheral Nervous System Diseases
• Retinopathy
• Type 1 Diabetes

• NCT number: NCT02321904
• Study type: Observational
• Source: University of Calgary
• Status: Completed
• Start date: June 2008
• Completion date: August 2019