Type 1 Diabetes Clinical Trial
Official title:
A Single Center, Open-Labeled Exploratory Study to Evaluate a Novel Method for Integrating Insulin Delivery and Glucose Sensing in Subcutaneous Tissue of Type-1 Diabetic Patients
The study seeks to use microdialysis and microperfusion techniques to assess the feasibility of performing insulin delivery and glucose sensing at a single subcutaneous tissue site.
Glucose management in type 1 diabetic patients comprises the measurement of glucose in
capillary blood obtained by fingersticking and administration of exogenous insulin in the
form of a subcutaneous bolus injection or continuous subcutaneous infusion.
The present study seeks to test an alternative treatment approach that combines glucose
measurement and insulin delivery at a single subcutaneous tissue site, thereby circumventing
the need for fingerstick blood glucose monitoring. Microperfusion and microdialysis probes
are applied in type 1 diabetic subjects to perform insulin delivery and glucose sampling at
the same adipose tissue site. The feasibility of estimating blood glucose concentrations
from the glucose levels measured at the subcutaneous insulin delivery site is then assessed
during an overnight fast and an oral glucose tolerance test.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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