Anaesthesia & Tryptophan Pathway NCT04466436

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Clinical Trial Details — Status: Recruiting

Surgery has many immunomodulatory properties of which the mechanism is not clearly understood.

surgery and anesthesia have a deleterious effect on immune system,studyingtryptophan pathway might give more information on their effect.

Recruitment information / eligibility
Status	Recruiting
Enrollment	48
Est. completion date	August 10, 2020
Est. primary completion date	August 8, 2020
Accepts healthy volunteers	No
Gender	All
Age group	N/A and older
Eligibility	Inclusion Criteria: - elective surgery Exclusion Criteria: - emergency surgery

Other:
• tryptophan
measurement of tryptophan in serum

Locations
Country	Name	City	State
Egypt	Assiut university	Assiut

Sponsors *(1)*
Lead Sponsor	Collaborator
Assiut University

Egypt,

Outcome
Type	Measure	Description	Time frame	Safety issue
Primary	tryptophan metabolites in serum		72 hours