Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)

Status Recruiting

Clinical Trial Summary

Prior research has identified profound sleep disruption in individuals with PSP. Not only were these individuals sleeping relatively short periods at night, they were also not recuperating lost sleep during the day. Research also showed the relative preservation of a series of nuclei key in regulating wake and arousal. Investigators believe that therapeutically targeting wake promoting centers with a specific medication will improve sleep quality and overall well-being in PSP. To study this, investigators will be doing a double blind, within subject, remote clinical trial with 3 conditions: suvorexant- which targets a wake promoting system, zolpidem- a standard hypnotic that engages sleep promoting systems, versus placebo. Each condition will last 1 week and will be separated by a 1 week washout period on no sleep medications. Investigators will measure sleep patterns and daytime symptoms to determine if suvorexant, zolpidem, or both medications are safe and effective for treating sleep disturbances and improving overall well-being in PSP.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04014387
Study type	Interventional
Source	University of California, San Francisco
Contact	Thomas Neylan, MD
Phone	415-750-6961
Email	Thomas.Neylan@ucsf.edu
Status	Recruiting
Phase	Phase 4
Start date	June 2, 2019
Completion date	May 15, 2025

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