Treatment Clinical Trial
Official title:
A PHASE II STUDY Of ADJUVANT CHEMOTHERAPY After SURGERY For STAGE I Lung ADENOCARCINOMA PATIENTS With MICROPAPILLARY COMPONENT More Than Or EQUAL To 20%
Randomized phase II trial aims to compare surgery with or without adjuvant chemotherapy in treating patients who are pathologically diagnosed as stage I lung adenocarcinoma with micropapillary component no less than 20%.
The presence of micropapillary component in adenocarcinoma is a predictor of poor prognosis,
and has been reported to be to be chemosensitive to platinum-based chemotherapy. Seeking a
more appropriate treatment for these patients, we perform this randomized phase II clinical
trial. About 460 stage I lung adenocarcinoma patients with micropapillary component ≥ 20%
will be included and divided into two group. Patients in the control group will only undergo
complete R0 resection of the lesion, no further therapy will be used. While patients in the
experimental group are going to receive platinum-based chemotherapy (comprising cisplatin and
pemetrexed disodium)about 1 month after therapeutic surgery. Treatment continues every 3
weeks for 4 courses. Clinic and telephone follow up will be conducted for survival data
monitoring.
DFS(disease free survival rate) and OS(overall survival rate) curves will be calculated using
the Kaplan-Meier, life-table method. Comparison of the survival curve for the two groups will
be performed using the log-rank test.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05243134 -
The Influence of Anatomic Deformities on the Clinical Efficacy in the Patients With Patellar Dislocation
|
||
| Completed |
NCT02486874 -
Clinical Evaluation of PoreSkin
|
Phase 1 | |
| Active, not recruiting |
NCT04592640 -
Stem Cells for Uremic Calciphylaxis Patients
|
N/A | |
| Recruiting |
NCT04599686 -
Stereotactic Body Radiotherapy (SBRT) for Oligometastatic Prostate Cancer
|
N/A | |
| Completed |
NCT02782442 -
Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM)
|
N/A | |
| Completed |
NCT03439930 -
The Effect of Balance Training on Neuromuscular Control in Subjects With CAI
|
N/A | |
| Not yet recruiting |
NCT05537155 -
Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery
|
N/A | |
| Recruiting |
NCT02971982 -
PCD Versus RCD for the Treatment of Patients With Waldenstrom's Macroglobulinemia
|
Phase 1/Phase 2 | |
| Completed |
NCT02820272 -
Water for Reducing Pain in Negative Pressure Wound Therapy
|
Phase 2 | |
| Completed |
NCT00984958 -
Bulkamid Treatment of Stress Incontinence in Women With Urinary Stress Incontinence and Not Suitable to TVT-procedure
|
N/A | |
| Completed |
NCT00575224 -
Pegasys and Copegus for Asian Patients With Treatment-naive Hepatitis C Genotypes 6, 7, 8, 9
|
Phase 4 | |
| Completed |
NCT00164307 -
Assisting Children With Prenatal Alcohol Exposure in Developing Peer Friendships
|
Phase 1/Phase 2 | |
| Completed |
NCT00164528 -
Intervening With Children/Adolescents With FAS/ARND
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04603586 -
Stereotactic Radiotherapy in Locally Advanced Pancreatic Cancer With Different Biological Effective Doses
|
N/A | |
| Recruiting |
NCT03375424 -
Vedolizumab Study With Inflammatory Bowel Disease Patients in Germany
|
N/A | |
| Not yet recruiting |
NCT04062370 -
Ranibizumab Treatment for Macular Edema Secondary to Retinal Vein Occlusion
|
Phase 4 | |
| Not yet recruiting |
NCT02931136 -
Early Diagnosis and Early Treatment of Alzheimer's Disease Based on Senile Plaque Imaging
|
Phase 4 | |
| Completed |
NCT04661228 -
Diagnostic Survey of Mental and Substance Use Disorders in HUNT (PsykHUNT)
|
||
| Recruiting |
NCT03365141 -
Efficacy of Intralesional Triamcinolone Injection in the Treatment of Vitiligo
|
N/A | |
| Recruiting |
NCT04599699 -
Integrated Boost to the Dominant Intraprostatic Nodule Based on Ga-68 PSMA PET/MR Study of SBRT With Prostate Cancer
|
N/A |