Traumatic Haemorrhage Clinical Trial
Official title:
Pharmacokinetics of Intramuscular Tranexamic Acid in Trauma Patients: a Clinical Trial
Intramuscular injection of tranexamic acid (TXA) would increase its use in situations where
administration of intravenous drugs is difficult. The investigators aim to assess the
population pharmacokinetics of intramuscular TXA in trauma patients.
Primary endpoint: Serum TXA concentrations over time. Secondary endpoints: Local reactions at
injection sites and adverse events
A prospective, open-label, multicentre, pharmacokinetic study conducted in the UK hospital. Potential eligible patients will have received a 1 gram IV dose of TXA at the scene of the injury or on arrival in hospital and a second dose is clinically indicated. ;