Trauma Clinical Trial
Official title:
Heart Rate Variability in Trauma Patients
The purpose of this study is to develop new triage tool for trauma patients based on HRV.
EKG will be prospectively measured in trauma patients in two locations: in the prehospital
setting (the field and during transport by helicopter) and in the hospital setting. In each
case HRV will be derived from the EKG signal, will be correlated with other non-invasive
signals (e.g. near infrared spectroscopy (NIR), and bispectral EEG (BIS)), along with other
routinely measured variables (blood pressure, respiratory rate, pulse oximetry, etc), will
be correlated with injury severity and day of discharge. An algorithm will be constructed
using multiple linear regression. The hypotheses are:
1. reduced HRV in the field correlates with bad outcome;
2. the specificity and efficiency of HRV as a screening tool can be improved by
controlling factors such as heart rate, age, gender, respiratory rate, and pulse oxygen
saturation;
3. an easy to interpret HRV index can be derived that can be used for trauma triage or
diagnosis.
The eligible study population will be comprised of patients who meet level 1 trauma criteria and are transported by helicopter to Ryder Trauma Center or who are already admitted to the trauma center for presumptive traumatic brain injury. In addition to the EKG, trauma patients may also be connected to either an non-invasive NIR Monitor, which provides real-time information about perfusion status and/or a bispectral EEG monitor, which provides real-time information about brain metabolic activity. ;
Observational Model: Cohort, Time Perspective: Prospective
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