Interaction Between Early Trauma & Odor-induced Dopamine Release

Status Not yet recruiting

Clinical Trial Summary

This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.

Clinical Trial Description

The occurrence of early trauma has been linked to alterations in the development of emotion regulation circuits and functional brain connectivity (particularly in the dorsolateral prefrontal cortex - DLPFC), the dopaminergic response to stress and an alteration in hedonicity (including olfactory hedonicity), which can lead to the onset of psychiatric disorders such as anxiety or depression. However, few studies have investigated the influence of early trauma on the release of dopamine (DA) evoked by odors with a positive emotional valence. Yet hedonicity is a key component of olfaction, as a positive odor leads to reinforced behavior in areas such as food intake and social interaction. This reinforcement process is thought to be underpinned by the very close link between the olfactory system (olfactory tubercle), the emotional regulation system (DLPFC) and the reward system (striatum), including the release of DA. The aim of the study is to investigate the influence of early trauma on DAergic transmission evoked by odorants with a positive emotional valence. To this end, 30 participants will be recruited and divided into two groups: those with early trauma and those without, according to their score on the Childhood Trauma Questionnaire. They will undergo an MRI-PET scan during which they will be exposed to pleasant odors. Subcortical dopaminergic transmission will be analyzed using the PET activity of [11C]Raclopride (a D2 receptor antagonist). Investigators hypothesize that early trauma resulting in abnormal cortico-subcortical and cortico-cortical connectivity would lead to a deficit in the hedonic appreciation of a pleasant odor, associated with a reduction in DAergic reactivity evoked in the reward system. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06284382
Study type	Interventional
Source	Hôpital le Vinatier
Contact	FILIPE GALVAO
Phone	0033437915565
Email	filipe.galvao@ch-le-vinatier.fr
Status	Not yet recruiting
Phase	N/A
Start date	June 1, 2024
Completion date	June 1, 2027

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05419934` - EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial	N/A
Completed	`NCT06014970` - The Health and Wellness Curriculum Assessment	N/A
Recruiting	`NCT04431531` - EMDR Pre-treatment Yoga for Complex Trauma	N/A
Completed	`NCT03966963` - Systematic Case Series Investigating Eye Movement Desensitization Reprocessing (EMDR) Efficacy With Childhood Sexual Abuse Survivors	N/A
Recruiting	`NCT03271437` - Flash Open Trial With Therapists In Training	N/A
Completed	`NCT04127526` - Psychological Therapy for Dissociation, Trauma and Voices: A Single Case Experimental Design	N/A
Enrolling by invitation	`NCT05600868` - The Effect of Dual Attention in an EMDR Intervention	N/A
Completed	`NCT04466163` - Strengthening the Healthy Adult Mode: a Case Experimental Study Exploring the Effects of a New Schema Therapy Protocol in an Adult Outpatient Population.	N/A
Active, not recruiting	`NCT05264415` - Intergenerational Transmission of Traumatic Stress	N/A
Completed	`NCT04587752` - Cognitive-Behavioral Therapy for Weight-related Bullying (Online Treatment)	N/A
Not yet recruiting	`NCT05039853` - Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task	N/A
Not yet recruiting	`NCT04104724` - CFT Self-Help for Accessing Cervical Screening After Sexual Assault	N/A
Completed	`NCT03970915` - Warm-up Efficiency by Body Warmer Versus Standard Procedure in Severely Traumatized Patients	N/A
Completed	`NCT04025463` - Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV	N/A
Completed	`NCT03145792` - Online Coping Skills Counseling for Problem Gambling and Trauma	N/A
Enrolling by invitation	`NCT04156373` - Fuerte Program for Newcomer Immigrant Youth	N/A
Completed	`NCT05048758` - Adverse Childhood Experiences in Alcohol Use Disorder
Active, not recruiting	`NCT03356028` - Pedopsychiatric and Multidisciplinary Research Devoted to Children Exposed to the Attack in Nice on July 14, 2016	N/A
Recruiting	`NCT04201184` - Wakȟáŋyeža (Little Holy One)	N/A
Completed	`NCT05627206` - The Impact of PM+For Moms Intervention on Improving Mother's Mental Health in Zambia (PM+FM)	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Interaction Between Early Trauma and Odor-induced Dopamine Release — T-ODOR

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms