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Prevalence of wtATTR-CM After Carpal Tunnel Release Surgery — CACTuS2  

Transthyretin Amyloidosis Clinical Trial

Official title:
Prevalence of Wild-Type Transthyretin Cardiac Amyloidosis Among Patients Undergoing Carpal Tunnel Release Surgery - A Prospective Study

Clinical Trial Summary

Patients above the age of 60 will be recruited at their carpal tunnel release surgery. Biopsies will be taken from the wrist and examined for the presence of amyloid protein. A amyloid-positive biopsy will refer the patients for cardiac examination including blod- and urine samples examined for transthyretin. If the result of the cardiac examination is suspected cardiac amyloidosis, the patient will be referred for a diagnostic TC99-DPD scintigraphy. If the scintigraphy is positive, the patient will be referred for right heart catherization (RHC) and an exercise test. Myocardial biopsies will be taken at the RHC and examined with electron microscopy and high resolution respirometry.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04276220
Study type Interventional
Source Aarhus University Hospital Skejby
Contact Sie Kronborg Fensman
Phone +45 30 48 88 85
Email siefen@rm.dk
Status Recruiting
Phase N/A
Start date April 1, 2020
Completion date January 2026
View Details
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