Transplantation Clinical Trial
Official title:
Monitoring Organ Donors to Increase Transplantation Results
The objective of this study is to determine whether protocol guided resuscitation of brain
dead organ donors using Pulse Pressure Variation (PPV) will increase the number of organs
transplanted per donor.
Specifically the study aims to:
1. improve resuscitation of potential organ donors.
2. improve organ function in donors.
3. increase organ recovery per donor.
The investigators will randomize 960 subjects to either protocolized resuscitation (n=480)
using a consensus-based PPV-guided algorithm or usual care using a 1:1 randomization scheme.
The primary outcome is the mean number of organs transplanted per donor. Secondary outcomes
include 6mHFS (six-month hospital-free survival) in the recipients, and mean number of organs
procured per donor that are suitable for transplantation (intention to transplant). The study
is powered to detect a 0.5 organ increase for transplantation per donor.
n/a
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