Transplantation Infection Clinical Trial
Official title:
Renal Sensing of the Acidifying Effect of Sulphur-containing Amino Acids: Consequences for the Relation Between Protein Intake and Blood Pressure in Renal Transplant Recipients
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, the investigators hypothesize that due to poor homeostatic capacity and necessary use of immunosuppressive and other drugs, renal transplant recipients are much more susceptible to poor dietary habits and exposure to potentially toxic contaminants than people of the general population, and that this contributes to accelerated function loss of the graft and excess risk of premature mortality, both contributing to poor long-term results. This study is a biobank and cohort study which investigates this hypothesis.
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term
(10-year and longer) results are, however, still disappointing. Where most research has
focused on immunosuppression and infections, the investigators hypothesize that due to poor
homeostatic capacity and necessary use of immunosuppressive and other drugs, renal transplant
recipients are much more susceptible to poor dietary habits and exposure to potentially toxic
contaminants than people of the general population, and that this contributes to accelerated
function loss of the graft and excess risk of premature mortality, both contributing to poor
long-term results.
To investigate one part of this overarching hypothesis, the investigators wrote a project on
around the specific topic of the relation between dietary acid load, ammoniagenesis and its
potential influence on blood pressure. The investigators used this project to build a biobank
and cohort in which they can test additional hypotheses on the relation between diet,
contaminants and development of graft failure and the occurrence of mortality.
The investigators also included 300 healthy controls to compare diet, contaminant exposure
and biomarkers with the renal transplant recipients.
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