Transplant Rejection Clinical Trial
— MARNIOfficial title:
Immunological Mechanisms of Rejection in Uterine Transplantation
The objective of this study is to understand the mechanisms of rejection in uterine transplantation and to search for non-invasive markers of rejection. The biological samples necessary for our research have been or will be collected during procedures (biopsies, smears, vaginal swab, blood tests) carried out as part of the scheduled follow-up of patients. These will be samples whose collection is minimally or not invasive
Status | Recruiting |
Enrollment | 30 |
Est. completion date | September 2028 |
Est. primary completion date | September 2025 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Patient going to or having received a uterine transplant OR Patient going to or having donated a uterus for a recipient included in the study OR Premenopausal woman to undergo gynecological surgery under general anesthesia: for 4 of them it was a hysterectomy and they must be under 45 years old, the other 6 must be under 38 years old. Exclusion Criteria (For witness): - Pregnancy in progress - Current infection - Cervical dysplasia - History of transplant or transfusion - Cancer or history of cancer - Menopause - Patient aged 38 or over for the 6 controls without hysterectomy, patient aged 45 or over for the 4 patients with hysterectomy. - Endometriosis |
Country | Name | City | State |
---|---|---|---|
France | Hopital Foch | Suresnes |
Lead Sponsor | Collaborator |
---|---|
Hopital Foch |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | presence of new markers associated with transplant rejection | 8 years | ||
Secondary | incidence of pregnancy on transplant immunology | 8 years | ||
Secondary | microbiota in uterine transplant | 8 years |
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