Transfusional Iron Overload Clinical Trial
Official title:
Extension Study of Iron Chelation Therapy With Deferasirox in Patients With Transfusional Iron Overload
A 1-year randomized Phase IIa core trial followed by a prolongation of 5 to 9 months was
conducted to investigate the efficacy and safety of deferasirox in patients aged ≥ 18 years
with transfusion-dependent iron overload.
The objective of this extension study is to assess the long-term safety of deferasirox and
to provide treatment in patients with transfusional iron overload.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00560820 -
Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload
|
Phase 1 | |
| Completed |
NCT00390858 -
A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.
|
Phase 2 | |
| Completed |
NCT01039636 -
Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload
|
Phase 1 | |
| Completed |
NCT00673608 -
Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload
|
Phase 4 | |
| Completed |
NCT00600938 -
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
|
Phase 2 | |
| Withdrawn |
NCT01927913 -
Treatment of Iron Overload Requiring Chelation Therapy
|
Phase 2 | |
| Completed |
NCT01241357 -
High-Tc Susceptometer to Monitor Transfusional Iron Overload
|
Phase 2 | |
| Completed |
NCT01838291 -
Active Drug Surveillance Program of Ferriprox Use
|
N/A | |
| Completed |
NCT01044186 -
A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe Toxicity
|
Phase 2 | |
| Terminated |
NCT01326845 -
Myelodysplastic Syndrome (MDS) Gastrointestinal (GI) Tolerability Study
|
Phase 4 | |
| Completed |
NCT01186419 -
Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload
|
Phase 2 | |
| Terminated |
NCT01363908 -
Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron Overload
|
Phase 2 |