Tracheal Stenosis Clinical Trial
Official title:
Role of Bronchoscopy in Assessment of Patients With Post-intubation Tracheal Stenosis
1. To estimate the importance of bronchoscopic treatment of tracheal stenosis and its effectiveness and safety. 2. To diagnose and evaluate tracheal stenosis characteristics as location, vertical extension and severity of obstruction.
Post intubation tracheal stenosis (PI) was recognized in 1880, after prolonged endotracheal intubation in 4 patients with upper airway obstruction.The most common causes of acquired tracheal stenosis are endotracheal intubation and tracheostomy. Tracheal stenosis is a surgical problem managed non operatively by bronchoscopic dilation, endoluminal treatment with lasers, and stenting. Bronchoscopic management have a good success rate. PI and post tracheostomy stenosis (PT) are recognized with an 4.9 cases per million per year in the general population. Prolonged intubation can result in tracheal stenosis at various levels within the trachea.Tracheal stenosis occurs at the endotracheal tube cuff site in one third of the reported PI cases [9] and appears as a web-like fibrous. The mainly postulated cause is loss of regional blood flow.This injury begins within the first hours of intubation, and healing of the damaged areas within 3 to 6 weeks. Large volume, low pressure cuffs has reduced the occurrence of cuff injury.Patients in the ICU are common to have respiratory involvement, with 30-50% of the admissions requiring the use of mechanical ventilation.Flexible bronchoscopy has become the procedure of choice in most examinations of the tracheobronchial tree.The incidence of PI tracheal stenosis ranges from 6-21% and following tracheostomy ranges from 0.6-21%. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Suspended |
NCT02949414 -
A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells
|
Phase 1 | |
| Not yet recruiting |
NCT03411928 -
Endotracheal Dilator to Improve Oxygenation
|
N/A | |
| Recruiting |
NCT05028023 -
Tracheal Dilatation in Pediatric Patients With Acquired Tracheal Stenosis, and the Effects of Apneic Oxygenation
|
N/A | |
| Completed |
NCT02796326 -
Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures
|
N/A | |
| Completed |
NCT06121024 -
Long-term Outcomes of Post-intubation Tracheal Stenosis; 7-year Follow-up
|
||
| Recruiting |
NCT02961387 -
A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study
|
N/A | |
| Completed |
NCT02855502 -
Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients
|
Phase 4 | |
| Completed |
NCT04674995 -
Stent Versus Balloon Dilatation in Patients With Tracheal Benign Stenosis
|
||
| Completed |
NCT01331863 -
Airway and/or Pulmonary Vessels Transplantation
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT05835713 -
Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam
|
N/A | |
| Suspended |
NCT02620319 -
Biodegradable Stents in the Management of Stenoses of the Large Airways
|
N/A | |
| Recruiting |
NCT03455881 -
Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
|
||
| Recruiting |
NCT04719845 -
DilAtation Versus Endoscopic Laser Resection in Simple Benign trAcheal sTEnosis
|
N/A | |
| Completed |
NCT05317923 -
Airway Management During Unusual Tracheal Stenosis
|
N/A | |
| Enrolling by invitation |
NCT05535803 -
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
|
Phase 2 | |
| Completed |
NCT00705848 -
Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis
|
N/A | |
| Completed |
NCT03130374 -
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
|
Phase 1/Phase 2 | |
| Completed |
NCT06061380 -
Challenges and Management of Post-intubation Tracheal Stenosis
|
||
| Enrolling by invitation |
NCT04850742 -
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices
|
N/A | |
| Completed |
NCT05682651 -
Relationship Between Post-Intubation Tracheal Stenosis and Covid-19
|