Tourette Syndrome Clinical Trial
OBJECTIVES: I. Characterize the natural history, associated features, and severity of
symptoms of obsessive compulsive disorder and Tourette syndrome in children and adolescents.
II. Identify factors that influence the clinical course and prognosis of these patients.
PROTOCOL OUTLINE: All patients and their families participate in 6 parts of the study:
current severity of symptoms, coincident disease diagnoses, natural history,
neuropsychologic assessment, physical and neurologic assessment, and family history and
function. The evaluations include the following: Current Severity of Symptoms Assessment,
Children's Yale Brown Obsessive Compulsive Scale (CY-BOCS), Clinician's Global
Impression-Obsessive Compulsive Disorder (CGI-OC), Leyton Obsessional Inventory-Child
Version (LOI-CV), Obsessive Compulsive Personality Rating Scale, Yale Global Tic Severity
Scale(YGTSS), Clinician's Global Impression-Tourette Syndrome (CGI-TS), Tourette Syndrome
Symptom List (TSSL), Clinician's Global Impression-Anxiety (CGI-A), Covi Anxiety Scale
(CAS), Children's Manifest Anxiety Scale-Revised (CMAS-R), Social Anxiety Scale for
Children-Revised, Fear Survey Schedule for Children-Revised, Louisville Fear Survey,
Children's Depression Rating Scale-Revised (CDRS-R), Clinician's Global
Impression-Depression (CGI-D), Children's Depression Inventory (CDI), The Dimensions of
Temperament Survey (DOTS), Mosher Guilt Scale-Revised, Real vs. Ideal Self Questionnaire,
Harter Self-Perception Profile For Children, The Children's Global Assessment Scale (CGAS),
The Child Behavior Checklist (CBCL), Coincident Disease Diagnoses Assessment, Diagnostic
Interview Schedule for Children-II (DISC-II), Yale Best Estimate of Diagnoses Schedule
(Y-BEDS), Natural History Evaluation, Yale Natural History Questionnaire (YHNQ), Social
Readjustment Scale for Children, Neuropsychologic Assessment, Delayed Response Tasks,
Continuous Performance Task, Continuous Recognition Memory, Selective Reminding Procedures,
Card Sorting Tasks, Wechsler Intelligence Scale for Children-Revised, Digit Span, Digit
Symbol and Mazes Paced Auditory, Serial Addition Task, Purdue Pegboard Trail Making Tasks,
Fluency Tasks, Rey-Osterreith Complex Figure Stanford-Binet Intelligence Scale-Fourth
Edition, Physical, Neurologic, and Neurochemical Assessment Physical exam (abbreviated),
Physical and Neurological Examination for Soft Signs (PANESS), 24-hour urinary cortisol and
catecholamines, Family History and Family Function Assessment of family history, Assessment
of Family Functioning.
The estimated duration of study is 10 years.
;
Primary Purpose: Screening
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