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Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction

Total Knee Arthroplasty Clinical Trial

Official title:
Efficiency of Donepezil in Elderly Patients Undergoing Orthopedic Surgery Due to Underlying Postoperative Cognitive Dysfunction, a Multicenter Randomized Controlled Trial

Clinical Trial Summary

Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to our previous study, the central cholinergic system impaired by the anesthesia and surgery play a very important role in the POCD and donepezil an acetylcholinesterase inhibitor can prevent the POCD after isoflurane anesthesia in aged mice. Donepezil is a commercial medicine used for the Alzheimer Disease, which is tolerable and has minimal adverse events. In present study a multi-center randomized case control study was conducted and we hypothesized that donepezil attenuate the POCD.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04423276
Study type Interventional
Source RenJi Hospital
Contact Diansan Su, M.D., Ph.D.
Phone +8618616514088
Email diansansu@yahoo.com
Status Recruiting
Phase Phase 4
Start date June 14, 2020
Completion date December 1, 2022
View Details
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