Total Intravenous Anesthesia Clinical Trial
Official title:
The Effect of Mild Hypercapnia During Anesthetic Emergence on Recovery Time From TIVA
We hypothesized that patients with mild hypercapnia during anesthetic emergence after TIVA had a shorter recovery time than patients with normal blood carbonate levels. We will select patients undergoing transurethral lithotripsy, who were expected to have mild postoperative pain, compare tracheal extubation time in patients with normal blood carbonic acid level and mild hypercapnia, to evaluate the effect of blood carbonic acid level during anesthetic emergence on recovery time from TIVA by. We also examined the changes of cerebral blood flow by TCD to investigate the possible mechanism of mild hypercapnia affecting the recovery time from TIVA.
Status | Recruiting |
Enrollment | 164 |
Est. completion date | June 1, 2023 |
Est. primary completion date | March 1, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Adult patients aged 20-60 years, with American Society of Anesthesiology physical status 1 to 2, undergoing transurethral lithotripsy under TIVA with endotracheal intubation; voluntarily signed informed consent forms. Exclusion Criteria: - Patients with mental, pulmonary, cardiac, endocrine, neuromuscular, liver and nervous system diseases or a history of such diseases; Lung CT showed atelectasis, pulmonary infection and pleural effusion. Patients taking sedatives or other drugs that might interfere with the study; Alcohol or drug dependence; Patients who have had a history of general anesthesia within the past month; Patients with body mass index (BMI) of 30 kg/m2 or above; Patients who are expected to be under anesthesia for less than 30 minutes; Patients with difficult airways. |
Country | Name | City | State |
---|---|---|---|
China | 2ndAffiliated Hospital, School of Medicine, Zhejiang University, China | Hangzhou | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
Second Affiliated Hospital, School of Medicine, Zhejiang University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Tracheal extubation time | The time from propofol infusion stopped to Tracheal extubation | 1 year | |
Secondary | Time of anesthesia | Time from anesthesia induction to cessation of propofol infusion | 1 year | |
Secondary | Total infusion of propofol and remifentanil | Total infusion of propofol and remifentanil | 1 year | |
Secondary | Spontaneous respiratory recovery time | The time from the beginning of cessation of propofol infusion to the time when the patient begins to cough or when the ETCO2 waveform changes | 1 year | |
Secondary | Time of eyes or mouth opening | The time from the beginning of cessation of propofol infusion to the time when patients can open their eyes or mouth | 1 year | |
Secondary | Changes in cerebral blood flow examined by transcranial Doppler (TCD) | Examine at the following four time points: before anesthesia induction; 10min after operation; After adjustment of ETCO2 is completed in post-anaesthesia care unit(PACU); 20 min after tracheal extubation | 1 year |
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