Variation in Rate of Orthodontic Tooth Movement in Response to Platelet Rich Plasma Therapy

Tooth Movement Clinical Trial

Official title:

Variation in Rate of Orthodontic Tooth Movement in Response to Platelet Rich Plasma Therapy

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04016727
• Other study ID #: platelet rich plasma
• Status: Active, not recruiting
• Phase: Phase 4
• Start date: July 2, 2018
• Est. completion date: February 2, 2020

Study information

• Verified date: January 2020
• Source: Armed Forces Institute of Dentistry, Pakistan
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

PRP from 5 ml blood was prepared and 60 units were injected into the buccal vestibule of patient before initiating canine retraction using NiTi coil spring. Pre and post cervical, incisal and mid distances were measured using Vernier calliper.

Description:

Platelet rich plasma was prepared using patients own blood. The production of PRP began with a 6-mL homologous blood sample that was withdrawn from the donor via venupuncture. One milliliter of the blood sample was set apart to determine the concentration of platelets and leukocytes in whole blood. The remaining 5 mL was mixed with an anticoagulant (3.8%, 1-mL sodium citrate) to prevent clotting. The blood sample was centrifuged at 113 g for 5 minutes to separate the plasma containing the platelets from the red cells. The plasma was drawn off the top and centrifuged for an additional 2 minutes at 3772 g to separate the platelets. Suitable platelet concentrations were achieved by the resuspension of PRP with plasma (high platelet concentration, 5 times the concentration in whole blood).

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 10
• Est. completion date: February 2, 2020
• Est. primary completion date: March 2, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 11 Years to 20 Years

Eligibility

Inclusion Criteria:

• patients requiring first premolar extractions

Exclusion Criteria:

• patients taking any drugs, steroids, NSAIDs and antibiotics

• patients with any co morbid conditions

Related Conditions & MeSH terms

• Tooth Movement

Intervention

Biological:
• platelet rich plasma
Platelet rich plasma was prepared using patients own blood. 60 units of PRP was injected on one side of the arch using insulin syringe. Each patient served as his/her own control (the side with PRP injected) and experimental group (the side without PRP injected). Whether the right or left side served as control or experimental was determined by lottery method. Patients were recalled after 4 weeks and the measurements were repeated again between lateral incisors and canines at mid, cervical and incisal of the teeth and their mean was recorded.

Locations

Country	Name	City	State
Pakistan	AFID	Rawalpindi	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
Armed Forces Institute of Dentistry, Pakistan

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	canine movement in mili meters	distance was measured using vernier caliper at mid cervical and incisal region	1 month