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NCT02942108 Clinical Trial

Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery

Tooth, Impacted Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02942108
Other study ID # 36/20
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 2016
Est. completion date April 2020

Study information
Verified date December 2022
Source University of Belgrade
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date April 2020
Est. primary completion date March 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 35 Years
Eligibility Inclusion Criteria: - bilaterally symmetrically impacted lower third molars Exclusion Criteria: - presence of intraoral infection - chronic orofacial pain - pregnancy/ lactation - heavy tobacco smokers - alcohol/ drug abuse - allergic reaction to medicaments used

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• piezo surgery

• conventional surgery

Locations
Country Name City State
Serbia School of Dental Medicine, University of Belgrade Belgrade

Sponsors (1)
Lead Sponsor Collaborator
University of Belgrade

Country where clinical trial is conducted

Serbia, 

Outcome
Type Measure Description Time frame Safety issue
Primary SOD activity in alveolar bone specimen Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery immediately after surgery
Primary VEGF levels in alveolar bone specimen immediately after surgery
Primary MMP-9 level in alveolar bone specimen immediately after surgery
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