Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT03208062 |
| Other study ID # |
BioBanca |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
May 31, 2017 |
| Est. completion date |
May 31, 2027 |
Study information
| Verified date |
February 2024 |
| Source |
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio |
| Contact |
Elena Cittera |
| Phone |
00390283502224 |
| Email |
elena.cittera[@]grupposandonato.it |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Musculoskeletal disorders are an heterogeneous group of diseases that represent one of the
major causes of disability. Considering the importance of studying these pathologies, it is
necessary to develop research lines based on the availability of human biological material
from highly clinically relevant patients. The purpose of this project is therefore the
establishment of a bank of biological material (biobank) to investigate important aspects
related to the pathologies of the musculoskeletal system through subsequent bio-molecular
characterization studies.
Description:
Musculoskeletal disorders constitute an heterogeneous group of diseases which represent one
of the major causes of disability. These include degenerative, traumatic, genetic, metabolic
and primitive and secondary tumor illnesses. Among the pathologies of the musculoskeletal
system are extremely widespread and rare. Among the earliest can be illnesses such as
osteoarthritis and osteoporosis which, due to their high frequency in the population, have a
high impact not only at the personal but also at social level. The study of these pathologies
to identify new therapeutic targets is therefore a goal of great strategic importance. In the
oncological field, the skeleton is also one of the most common metastatic sites along with
lung, brain and liver. Bone metastases have devastating effects on the quality of life of
affected patients and result from the activation of extremely complex molecular mechanisms
whose comprehension would allow identification of targets for their prevention and treatment,
a key goal to date still reached. Unlike secondary bone tumors, primary tumors are a rare
group of tumors. As such, research into these types of pathologies has often been limited by
the low availability of human samples. Further characterization of these tumors is still
necessary to promote proper recognition and improve treatment.
Considering the importance of studying these pathologies, it is necessary to establish a
biobank of highly valuable biological material that would be the fundamental basis for the
subsequent setting up and activation of research projects. The establishment of biobanks has
been a fundamental support for the development of many research projects in a wide variety of
fields. Currently there isn't a biobank at IRCCS Galeazzi Orthopedic Institute. The purpose
of this project is therefore the creation of a biobank to investigate relevant aspects
related to musculoskeletal disorders through subsequent bio-molecular characterization
studies.
