Clinical Trials Logo
  1. Home
  2. TIA
  3. NCT03050099

SpecTRA; An Observational Study of the Verification of Protein Biomarkers in Transient Ischemic Attack.

TIA Clinical Trial

Official title:
Spectrometry for TIA Rapid Assessment (SpecTRA) Project: Study 1 Cohort 1A and 1B—Verification of Protein Biomarkers

Clinical Trial Summary

A multi-protein test using mass spectrometry (MS) for multiplexed protein quantitation is being developed. This test and the accompanying decision-aid software will provide Transient Ischemic Attack (TIA) results rapidly for a fraction of the price of neuroimaging. With guidance provided by this test, Emergency Department (ED) physicians can manage medical imaging questions such as the use of Computed Tomography Angiography (CTA) prior to ED discharge and appropriate (timely) referral to stroke clinics for consultation and follow-up care. The right patients will receive the right treatment, reduce unwarranted imaging risks and costs, and reduce the burden of stroke.

Clinical Trial Description

This study represents an initial Verification study, in which Mass Spectrometry will be used to quantify a large number of blood proteins previously implicated in ACVS and mimic conditions in patients who are consented and enrolled in the Emergency Department within 24 hrs of symptom onset. 560 patients will be enrolled, and grouped into two cohorts (Cohort 1A: 220; and Cohort 1B: 350).

In Cohort 1A, each consented participant provides three blood samples: on arrival, 4-6 hours later, then ~24 hours after that, but no later than 32 hours from symptom onset. In cohort 1b, each patient provides only a single blood sample up to 24 hours from symptom onset.

A positive diffusion-weighted imaging (DWI) signal on Magnetic Resonance Imaging (MRI) or definite ischemia on Computed tomography (CT) or vascular occlusion on CTA will be used as proof of ischemia to classify the clinical phenotype into three groups (see below). A neurologist will adjudicate all cases according to a study defined adjudication protocol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03050099
Study type Observational
Source Vancouver Island Health Authority
Contact
Status Completed
Phase N/A
Start date December 1, 2013
Completion date December 31, 2016
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05518305 - Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
Active, not recruiting NCT04011514 - Querying Stroke Unit Nursing Interventions in the Emergency Department
Not yet recruiting NCT01923818 - Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events Phase 2/Phase 3
Recruiting NCT03568890 - Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure Phase 4
Recruiting NCT05529901 - Japan Post Marketing Surveillance of the GORE® CARDIOFORM Septal Occluder
Completed NCT01942031 - Improved Prevention of Stroke in Primary Care in Stockholm, Sweden (Förbättrad Prevention av Stroke) N/A
Terminated NCT01018355 - The Effect of Device Closure of Patent Foramen Ovale in Elderly Patients With Crytogenic Stoke/TCI N/A
Terminated NCT01236508 - Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease Phase 4
Recruiting NCT03749057 - Early Rivaroxaban for Acute Ischemic Stroke or TIA Patients With Atrial Fibrillation Phase 4
Completed NCT03555643 - Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients
Recruiting NCT03812653 - Sleep for Stroke Management and Recovery Trial N/A
Terminated NCT03660618 - LSFG-SKIN, Laser Speckle Flowgraphy N/A
Completed NCT01648985 - Diabetes in Minor Stroke/TIA, Glucose Tolerance and Haemostasis, a Long-term-follow-up Study and Intervention With Yoga
Completed NCT03937934 - Study Title: Food Rx N/A
Recruiting NCT05476991 - Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis Phase 3
Not yet recruiting NCT06315192 - Stroke Alarm Efficacy Trial N/A
Recruiting NCT05730465 - Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure Monitor N/A
Active, not recruiting NCT05822791 - Differences in ECG- vs. proLonged cardIac MonItor-DeTected Atrial Fibrillation in STROKE Patients (DELIMIT AF-STROKE)
Completed NCT01645306 - Revacept in Symptomatic Carotid Stenosis Phase 2
Not yet recruiting NCT06319846 - Tirofiban for Patients With intraCranial Artery Stenosis and High-risk Acute Non-disabling Cerebrovascular Events(CHANCE-4） Phase 3