Comparison of Lidocaine and Remifentanil for the Effect on Responses to the Endotracheal Tube During Emergence From General Anesthesia

Thyroidectomy Clinical Trial

Official title:

Comparison of Lidocaine and Remifentanil for the Effect on Responses to the Endotracheal Tube During Emergence From General Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01082458
• Other study ID #: 4-2009-0519
• Status: Completed
• Phase: N/A
• First received: March 4, 2010
• Last updated: November 18, 2010
• Start date: February 2010
• Est. completion date: July 2010

Study information

• Verified date: November 2010
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

Target concentration infusion(TCI) of remifentanil (2.0ng/ml) suppresses the cough induced by endotracheal tube more effectively than intravenous administration of lidocaine (1.5mg/kg).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 67
• Est. completion date: July 2010
• Est. primary completion date: July 2010
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Females older than 20 years old

Exclusion Criteria:

• Patients with acute or chronic respiratory disease, hypertension, gastro-esophageal reflux disease, having preoperative sedatives or mucolytics, and current smoker.

Study Design

Primary Purpose: Prevention

Related Conditions & MeSH terms

• Thyroidectomy

Intervention

Drug:
• remifentanil / lidocaine
Remifentanil TCI group : target controlled infusion of 2.0ng/ml of remifentanil on end of surgery. Lidocaine IV group : Intravenous administration of 1.5mg/kg of lidocaine on end of surgery.

Locations

Country	Name	City	State
Korea, Republic of	Severance Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of lidocaine and remifentanil for the effect on responses to the endotracheal tube during emergence from general anesthesia	The incidence and the grade of cough during emergence from general anensthesia between remifentanil TCI group and lidocaine IV administration group.		No