Thyroid Clinical Trial
Official title:
A Strategy to Search for Genes Predisposing to Papillary Carcinoma of the Thyroid When Mutated
NCT number | NCT02776969 |
Other study ID # | OSU-9812 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | August 5, 1998 |
Est. completion date | December 2023 |
The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.
Status | Recruiting |
Enrollment | 1200 |
Est. completion date | December 2023 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives - Affected and unaffected family members of the proband* - For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples. Exclusion Criteria: - Known germline predisposition (ex: pathogenic PTEN variant) - Non-English speaking |
Country | Name | City | State |
---|---|---|---|
United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
Lead Sponsor | Collaborator |
---|---|
Ohio State University Comprehensive Cancer Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Genetic variants associated with familial papillary thyroid cancer as assessed by multiple genetic testing methodologies | Variants will be assessed for segregation within families, expression in the normal thyroid and/or thyroid cancer, and functional significance | Up to 5 years |
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