Thyroid Clinical Trial
Official title:
Randomized Trial Comparing Performance of Molecular Markers for Indeterminate Thyroid Nodules
The purpose of this study is to compare the performance of Afirma GSC and ThyroSeq v.3 in indeterminate thyroid nodules to determine which test can allow more patients to avoid unnecessary surgery and preserve quality of life. In the initial phase of this study, the performance of Afirma GEC and ThyroSeq v.2 were compared.
1. All patients undergoing thyroid FNA within the UCLA Health System will be randomized at the time of FNA to a single molecular test (GSC or ThyroSeq v.3). In the previous phase of the study, patients were randomized to the previous versions of a single molecular test (GEC or ThyroSeq v.2). 2. During the FNA, a sample will be collected for the molecular test. 3. If the cytology results are indeterminate (Bethesda categories 3 or 4), the molecular test will be reflexively sent off. 4. We will help patients with indeterminate thyroid nodules to establish care with an endocrinologist, if they do not already have one. The physicians will make treatment recommendations using best practices and incorporating the results of the molecular test. We anticipate that most patients with a positive molecular test will undergo surgery, while the majority with a negative test will be surveiled. 5. Patients who undergo surgery will have histopathologic evaluation of the thyroid, which will determine whether the index thyroid nodule was benign or malignant. 6. Patients who do not undergo surgery will have a followup ultrasound at 6 and 12 months, or sooner at the discretion of the treating physician. 7. We will assess thyroid-specific quality of life at baseline (following initial diagnosis of an indeterminate thyroid nodule) and during followup (at 6 and 12 months) using the short version of Thyroid-Related Patient-Reported Outcome. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT04085913 -
Exparel Injection Effect on Postoperative Opioid Usage
|
Early Phase 1 | |
| Completed |
NCT04647006 -
Comparison of TOETVA and Conventional Thyroidectomy
|
N/A | |
| Completed |
NCT04763122 -
Thyroid Cancer in United Arab Emirates
|
||
| Completed |
NCT05323539 -
Comparison of Thyroid Volumes in Patients With and Without Endometrioma
|
N/A | |
| Recruiting |
NCT04160637 -
Is There Benefit From Early Postoperative PTH Monitoring?
|
||
| Completed |
NCT03597659 -
PheWAS of a Polygenic Predictor of Thyroid Function
|
||
| Completed |
NCT03430141 -
A Nutritarian Study to Evaluate the Effectiveness of Lifestyle Changes in Chronic Disease Prevention, Especially Cancer
|
N/A | |
| Recruiting |
NCT04115514 -
Treatment of ARDS With Instilled T3
|
Phase 2 | |
| Recruiting |
NCT04623801 -
Laser Ablation of Papillary Thyroid Microcarcinoma
|
Phase 2 | |
| Recruiting |
NCT03754621 -
Upper Limit for TSH of First and Second Trimester Pregnancy in Turkey
|
||
| Withdrawn |
NCT03060499 -
Post Thyroidectomy Myocardial Function
|
||
| Completed |
NCT05276271 -
The Effect of Levetiracetam on Lipid Profile in Children
|
||
| Recruiting |
NCT04014660 -
Prevention av Autoimmunitet Med Laktobaciller
|
N/A | |
| Completed |
NCT02304172 -
The Efficacy and Safety of Thunderbeat in Thyroid Surgery
|
N/A | |
| Recruiting |
NCT04571736 -
Pilot Study for Thyroid Surgery by Preoperative Video Support and Personalized and Secure Web Platform
|
N/A | |
| Recruiting |
NCT05510609 -
Three-dimensional Ultrasonography Thyroid Volume Measurement.
|
N/A | |
| Active, not recruiting |
NCT05328076 -
Parathyroid Vascularization During Total Thyroidectomy Using Indocyanine Green Angiography
|
||
| Not yet recruiting |
NCT06377943 -
The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females
|
||
| Recruiting |
NCT03933358 -
Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients
|
||
| Completed |
NCT03816371 -
The Effects of Different Degrees of Head-of-bed Elevation
|
N/A |