Clinical Trials Logo
  1. Home
  2. Thyroid Nodule
  3. NCT03160482
  4. Details
NCT03160482 Clinical Trial

PACE4 in Thyroid Cancer

Thyroid Nodule Clinical Trial

Official title:
Evaluation of PACE4 Isoforms as Biomarkers in Thyroid Cancer

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03160482
Other study ID # 2017-1620
Secondary ID
Status Completed
Phase
First received
Last updated
Start date May 15, 2017
Est. completion date January 15, 2018

Study information
Verified date September 2018
Source Université de Sherbrooke
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no fully reliable molecular marker for thyroid cancer have been described. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a biomarker.

Description:

Patients that underwent thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and classified according to the pathological diagnosis. An immunohistochemistry technique, developed and calibrated for the specific protein convertase studied, will be undertaken. Results will be interpreted by a specialized pathologist.

Recruitment information / eligibility
Status Completed
Enrollment 39
Est. completion date January 15, 2018
Est. primary completion date January 15, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- Men of women, aged 18-100 y.-o.

- History of subtotal or total thyroidectomy at the "Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke" (CIUSSS de l'Estrie - CHUS) between January 2010 and May 2016.

Exclusion Criteria:

- Refusal to participate to the study.

- Unavailability of the formalin-fixed, paraffin-embedded tissues.

- Uncertain pathological diagnosis.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Immunohistochemistry
Immunohistochemistry procedure on the formalin-fixed, paraffin-embedded tissue.

Locations
Country Name City State
Canada CIUSSS de l'Estrie - CHUS Sherbrooke Quebec

Sponsors (1)
Lead Sponsor Collaborator
Robert Day

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Expression pattern of the studied protein convertase Horseradish peroxidase staining with specific antibodies. Trough study completion, an average of 1 year after the patients have been operated.
See also
  Status Clinical Trial Phase
Terminated NCT04614389 - Utility of Contrast-Enhanced Sonography and Shear Wave Elastography N/A
Recruiting NCT03295955 - Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy N/A
Completed NCT04647006 - Comparison of TOETVA and Conventional Thyroidectomy N/A
Not yet recruiting NCT06029946 - B-mode Ultrasound, Sono-Elastography, and Diffusion-weighted Imaging MRI in Thyroid Nodules
Recruiting NCT05025046 - NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules
Terminated NCT01320813 - Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy N/A
Completed NCT00877630 - Minimal Invasiveness of Endoscopic Thyroidectomy N/A
Completed NCT01964508 - microRNA in Thyroid Cancer
Completed NCT06306599 - Ultrasound Operator Influence on Diagnostics With AI for Thyroid Nodules - Clinial Trial N/A
Recruiting NCT04730726 - In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules N/A
Not yet recruiting NCT03884140 - Clinical Diagnostic Approach for Cases of Thyroid Nodules
Completed NCT04277455 - Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules N/A
Recruiting NCT02225509 - Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology N/A
Completed NCT00552253 - Levothyroxine Treatment in Thyroid Benign Nodular Goiter N/A
Not yet recruiting NCT03700762 - Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules.
Enrolling by invitation NCT01757834 - Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules N/A
Completed NCT01292044 - The Role of Elastography in the Diagnosis of Thyroid Nodules N/A
Completed NCT00858104 - Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Phase 4
Completed NCT00651625 - Reciprocating Medical Devices - a Study of a New Safety Device N/A
Completed NCT05132478 - The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer N/A