Influence of Thyroid Hormones on the Woundhealing Process

Thyroid Neoplasms Clinical Trial

Official title: Clinical Investigations on Cytokin-Gradients in Hypo/Euthyroid Patients. Evaluation of Expression of Different Pro-and Anti-Inflammatory Cyto-/Chemokines in Skin Wounds After Surgery of Benign Goitres (Struma Multinodosa) or Malignant Diseases of Thyroid Gland (Papillary Thyroid Carcinoma) in Correlation to the Status of Wound Healing of the Neck Wound

Status Recruiting

Clinical Trial Summary

Main goal of this clinical investigation is to investigate different cytokines in wound fluids of euthyroid vs. hypothyroid patients. As a primary endpoint we want to evaluate if different cytokine levels in euthyroid vs. hypothyroid patients exist and to what extent these cytokines differ. Our targeted cytokines are: IL6, IL10, TNFa and MCP-1. From the literature these 4 factors seem to be the most reasonable to measure and to focus on. Additionally we focus on these 4 factors for financial reasons, technically there wouldn't be a problem to measure more, which is correlated with higher costs. Besides, more than 6 factors would mean larger amounts of sample fluids needed, which would cause technical problems. These factors don`t have to change in the same direction. Secondarily, we believe that differences in cytokine profiles of hypothyroidism vs. euthyroidism will correlate to differences in duration and clinical characteristics of the wound healing process.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Thyroid Carcinoma
• Thyroid Diseases
• Thyroid Neoplasms

• NCT number: NCT00929318
• Study type: Interventional
• Source: Hannover Medical School
• Contact: Stephan S Kaaden, Dr
• Phone: 0049-511-532 6131
• Email: Kaaden.Stephan@mh-hannover.de
• Status: Recruiting
• Phase: N/A
• Start date: June 2009
• Completion date: April 2010