Thyroid Cancer Clinical Trial
Official title:
Method of Endogenous TSH Stimulation in the Follow-up of Differentiated Thyroid Cancer
The treatment of differentiated thyroid cancer (DCT) includes surgery followed by radioiodine treatment. In the follow-up of patients it is necessary to induce TSH elevation to test for cancer recurrence. One of the options is to stop L-thyroxin replacement for several weeks. Current pilot study aims to induce the necessary TSH elevation by decreasing the L-thyroxin dose. The main hypothesis is that necessary TSH stimulation will be achieved during 4-6 weeks in majority of patients.
The treatment of differentiated thyroid cancer (DCT) includes surgery followed by
radioiodine treatment. In the follow-up of patients it is necessary to induce TSH elevation
for the measurement of thyreoglobulin and/or total body scanning. There are two principal
methods to obtain TSH elevation: 1) injection of recombinant human TSH , and 2) to stop
L-thyroxin replacement for several (3-4) weeks. As use of recombinant TSH is rather
expensive, this method is not feasible in many countries. The problem with stopping
L-thyroxin is development of severe hypothyroidism for several weeks with concomitant
symptoms and signs.
Current pilot study aims to induce the necessary TSH elevation by decreasing the L-thyroxin
dose. The main hypothesis is that necessary TSH stimulation will be achieved during 4-6
weeks in majority of patients with fixed dose of L-thyroxin. Concomitantly, blood tests and
symptoms and signs of hypothyroidism will be obtained to get information about possible
deviations during treatment with low dose of thyroxin.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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