Thyroid Cancer Clinical Trial
Official title:
Study to Improve Thyroid Doses From Fallout Exposure in Kazakhstan
Verified date | August 17, 2017 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Residents of certain villages in Kazakhstan were exposed during childhood to radioactive
fallout from nuclear tests conducted at the Semipalatinsk Nuclear Test Site (SNTS) between
1949 and 1962.
Radiation doses to the thyroid from external and internal (i.e., ingested) radiation sources
deposited as fallout are of interest because they may be jointly and differentially
associated with increased risk of thyroid disease in this population.
Objectives:
To collect information about factors influencing radiation dose to the thyroid gland in
children of two ethnic groups who were exposed to radioactive fallout from nuclear tests at
the SNTS between 1949 and 1962. The two groups are Kazakhs (historically nomadic herders) and
Europeans (typically descendants of Russian and German farmers).
Eligibility:
Women 70 years of age and older who had children or provided care to children during the
1950s.
Men age 70 and older who were engaged in farming and care of dairy animals at the time of the
nuclear tests.
Design:
In focus group format, participants are interviewed to collect information on the following
at the time of nuclear tests:
- Dairy consumption;
- Source, storage and availability of milk and milk products;
- Time that children of different ages and ethnic groups spent indoors;
- Building material of houses and schools;
- Herding, grazing and supplemental feed of dairy animals.
Status | Completed |
Enrollment | 117 |
Est. completion date | August 17, 2017 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years to 90 Years |
Eligibility |
- To be eligible, individuals must speak Russian or Kazakh, be able to participate in a
two-hour focus group session, and have a verified history of residing in the village
during the 1950s. Verification of residence history will be based on regional records. 1. Women: In each village, we will recruit 24 women. We will select women who are age 70 years and older and who had children or provided care to children (i.e., younger siblings, nieces and nephews) during the 1950s. Our first priority is to recruit women whose own children were less than 21 years during the 1950s. If necessary, we will also recruit women who provided care to children other than their own (e.g., younger siblings, nieces and nephews) during this period. We will recruit both members of our 1998 cohort members and other women in the community who meet the eligibility criteria. Subjects will be chosen to represent experience caring for children of different ages at the time of the nuclear tests. In order to recruit women who had children of different ages (less than 21 years) during the 1950s, we will screen potential participants for their children s years of birth and attempt to enroll women whose children represent a range of ages during the 1950 s. 2. Men: In each village, we will recruit eight men (Russian and Kazakh) age 70 and older who were engaged in farming and care of dairy animals at the time of the nuclear tests. |
Country | Name | City | State |
---|---|---|---|
Kazakhstan | Semipalatinsk State Medical Academy | Semipalatinsk |
Lead Sponsor | Collaborator |
---|---|
National Cancer Institute (NCI) |
Kazakhstan,
Anspaugh LR, Simon SL, Gordeev KI, Likhtarev IA, Maxwell RM, Shinkarev SM. Movement of radionuclides in terrestrial ecosystems by physical processes. Health Phys. 2002 May;82(5):669-79. — View Citation
Bogdanova TI, Zurnadzhy LY, Greenebaum E, McConnell RJ, Robbins J, Epstein OV, Olijnyk VA, Hatch M, Zablotska LB, Tronko MD. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: pathology analysis of thyroid cancer cases in Ukraine detected during the first screening (1998-2000). Cancer. 2006 Dec 1;107(11):2559-66. — View Citation
Degteva MO, Vorobiova MI, Tolstykh EI, Shagina NB, Shishkina EA, Anspaugh LR, Napier BA, Bougrov NG, Shved VA, Tokareva EE. Development of an improved dose reconstruction system for the Techa River population affected by the operation of the Mayak Production Association. Radiat Res. 2006 Jul;166(1 Pt 2):255-70. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Thyroid nodules | 1998 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05774535 -
Prospective, Observational Study on the Carotid Intima-media Thickness in Patients Undergoing Thyroid Surgery
|
||
Withdrawn |
NCT04224792 -
Effects of Exercise Training on Fatigue in Thyroid Cancer Survivors
|
N/A | |
Completed |
NCT01728623 -
A Study of E7080 in Subjects With Advanced Thyroid Cancer
|
Phase 2 | |
Recruiting |
NCT03175224 -
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
|
Phase 2 | |
Completed |
NCT02911155 -
Cancer and Other Disease Risks in U.S. Nuclear Medicine Technologists
|
||
Recruiting |
NCT05025046 -
NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules
|
||
Not yet recruiting |
NCT03978351 -
The Role of Midkine in Diagnosis of Thyroid Cancer
|
||
Completed |
NCT02658513 -
Evaluation of Lancet Blood Sampling for Radioiodine Dosimetry in Thyroid Cancer
|
||
Terminated |
NCT02628535 -
Safety Study of MGD009 in B7-H3-expressing Tumors
|
Phase 1 | |
Withdrawn |
NCT01994200 -
Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) for Thyroid Cancer Patients
|
Phase 1/Phase 2 | |
Completed |
NCT02375451 -
Effect of Childhood Radioiodine Therapy on Salivary Function
|
N/A | |
Terminated |
NCT01403324 -
Comparison of Dosimetry After rhTSH or Withdrawal of Thyroid Hormone in Metastatic or Locally Advanced Thyroid Cancer
|
N/A | |
Completed |
NCT00970359 -
Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244
|
N/A | |
Completed |
NCT00439478 -
Dental Safety Profile of High-Dose Radioiodine Therapy
|
Phase 4 | |
Completed |
NCT00223158 -
Evaluation Study of L-T3 Utility in the Follow-up of Patients With Thyroid Cancer
|
N/A | |
Active, not recruiting |
NCT04544111 -
PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer
|
Phase 2 | |
Completed |
NCT04876287 -
Salivary dysfuncTion After Radioiodine Treatment
|
||
Recruiting |
NCT06073223 -
Intervention to Decrease Overtreatment of Patients With Low-risk Thyroid Cancer
|
N/A | |
Recruiting |
NCT06037174 -
Comparison of Quality of Life in Patients With Differentiated Thyroid Carcinoma Undergoing Different Surgery
|
||
Recruiting |
NCT04952493 -
Anlotinib or Penpulimab in Combination With RAI for DTC
|
Phase 2 |