Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging

Thymic Epithelial Tumor Clinical Trial

Official title:

Preoperative Prediction of the Pathological Classification of Thymic Epithelial Tumors by Apparent Diffusion Coefficient Using Ultra-high B-values

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03212027
• Other study ID #: 2016SF-211
• Status: Not yet recruiting
• Phase: N/A
• First received: July 6, 2017
• Last updated: July 13, 2017
• Start date: July 31, 2017
• Est. completion date: May 1, 2018

Study information

• Verified date: July 2017
• Source: Tang-Du Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to analyze aquaporins expression of thymic epithelial tumors and to compare them with apparent diffusion coefficient(ADC) from ultra-high b-values, and to test a possibility of use of ADCuh to identify the pathological type of tumor.

Description:

Magnetic resonance (MR) diffusion-weighted imaging (DWI) measures water diffusion in biological tissue. The quantification of diffusion is described by the apparent diffusion coefficient (ADC),which largely depends on the number and separation of barriers.Thus, ADC can provide information regarding tissue microstructure.

According to the literature, ADC is also related to cell membrane permeability for water molecules.It is well known that cellular water transport depends on aquaporins (AQPs).In general,the expression of aquaporins might differ in several pathologic disorders. With reference to this fact,we hypothesize that AQPs expression may influence ADC in thymic epithelial tumors(TETs).Therefore,the aim of the present study is to analyze possible associations between ADC from ultra-high b-values and AQPs expression(ADCuh) in TETs and to use ADCuh to identify the pathological type of tumor.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: May 1, 2018
• Est. primary completion date: January 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• no use of corticosteroid drugs;

• no MRI contraindication;

• no infection or fever;

• tumor diameter is greater than 2cm.

Exclusion Criteria:

Related Conditions & MeSH terms

• Neoplasms, Glandular and Epithelial
• Thymic Epithelial Tumor
• Thymus Neoplasms

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Tang-Du Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Different DWI parameters in thymic epithelial tumors		6 months
Secondary	To acquire aquaporins expression level of thymic epithelial tumors		6 months