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Clinical Trial Summary

The intent of the study is to assess the antitumor activity of PHA-848125AC as second-line treatment in patients with recurrent or metastatic, unresectable thymic carcinoma previously treated with chemotherapy.


Clinical Trial Description

The Simon's optimal 2 stage design is adopted for this single-arm, open-label, multicenter phase II clinical trial of PHA-848125AC administered to patients with recurrent or metastatic, unresectable thymic carcinoma previously treated with chemotherapy (only one prior systemic therapy allowed). The intent of the study is to assess the antitumor activity of PHA-848125AC and ultimately to improve the outcome of patients with thymic carcinoma who have already exploited one chemotherapy option. The primary end point for this study is a progression free survival rate of 3 months. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01011439
Study type Interventional
Source Tiziana Life Sciences, PLC
Contact
Status Terminated
Phase Phase 2
Start date February 22, 2010
Completion date December 17, 2018

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