Routine Transcervical Thymectomy in MEN-1 Patients

Thymic Carcinoid Clinical Trial

Official title:

Revisiting the Evidence for Routine Transcervical Thymectomy for the Prevention of Thymic Carcinoid Tumours in MEN-1 Patients a Case Series

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05061784
• Other study ID #: exempt from review
• Status: Completed
• Start date: July 14, 2021
• Est. completion date: August 20, 2021

Study information

• Verified date: September 2021
• Source: National University Health System, Singapore
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Description:

Introduction and Importance Malignant thymic carcinoids are uncommon but important entities among patients with multiple endocrine neoplasia type 1 (MEN-1). Current treatment guidelines advise the performance of a routine transcervical thymectomy (TCT) during parathyroidectomy, to prevent its development, although data on the yield of this prophylactic TCT is scarce. We aimed to revisit available literature to investigate and summarize the efficacy of routine TCT during neck exploration for parathyroidectomy, for the prevention of thymic carcinoid tumours among MEN-1 patients.

Methods A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 7
• Est. completion date: August 20, 2021
• Est. primary completion date: August 20, 2021
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Studies including MEN-1 patients who underwent a routine thymectomy during parathyoidectomy

• We accepted randomized controlled trials or observational studies that included patients of any age who underwent a routine TCT in the setting for MEN-1, published as full-length articles in peer-reviewed journals, which mentioned data on thymic carcinoid tumours.

Exclusion Criteria:

• We excluded reviews, letters, conference proceedings and non-English publications.

Related Conditions & MeSH terms

• Carcinoid Tumor
• Endocrine Gland Neoplasms
• Multiple Endocrine Neoplasia
• Multiple Endocrine Neoplasia Type 1
• Thymic Carcinoid

Intervention

Procedure:
• Routine thymectomy, which has been performed
There is no intervention

Locations

Country	Name	City	State
Singapore	National University Hospital	Singapore

Sponsors (1)

Lead Sponsor	Collaborator
National University Health System, Singapore

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of thyme carcinoid	Retrospective review of published studies	The timeframe will be from date of transcervical thymectomy until the date of documented diagnosis of diagnosis of thymic NET; progression of disease or date of death from any cause, whichever came first, assessed up to 100 months.