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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04081220
Other study ID # CTMS# 19-0078
Secondary ID HSC20190791H
Status Recruiting
Phase Phase 2
First received
Last updated
Start date April 9, 2020
Est. completion date January 2025

Study information

Verified date June 2023
Source The University of Texas Health Science Center at San Antonio
Contact Epp Goodwin
Phone 210-450-5798
Email goodwine@uthscsa.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This is a single-center, open-label investigator-initiated trial evaluating the effects of IMG-7289 administered orally once daily in patients with essential thrombocythemia.


Recruitment information / eligibility

Status Recruiting
Enrollment 20
Est. completion date January 2025
Est. primary completion date January 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age =18 years. - Diagnosis of Essential Thrombocythemia per World Health Organization (WHO) diagnostic criteria for myeloproliferative neoplasms (Arber et al., 2016). - 3. Patients who are intolerant or resistant to hydroxyurea per ELN (European Leukemia Net) criteria, or in the Investigator's judgment are not candidates for available approved therapy. The ELN definitions of resistance/intolerance to HU (hydroxyurea) requires the fulfillment of at least one of the following criteria: - Platelet count greater than 600 × 109/L after 3 months of at least 2 g/day of HU (2.5 g/day in patients with a body weight over 80 kg); - Platelet count greater than 400 × 109/L and leukocytes less than 2.5 × 109/L or hemoglobin (Hb) less than 100 g/L at any dose of HU; - Presence of leg ulcers or other unacceptable mucocutaneous manifestations at any dose of HU; - HU-related fever. - Requires treatment in order to lower platelet counts based on the Clinically Relevant IPSET (International Prognostic Score for Thrombosis in Essential Thrombocythemia) -Thrombosis Guidelines. - Platelet count >450 x 109/L pre-dose Day 1. - Peripheral blast count <10% pre-dose Day 1. - ANC (absolute neutrophil count) =0.5 x 109/L pre-dose Day 1. - Fibrosis Score = grade 2, as per a slightly modified version (Arber et al., 2016) of the European Consensus Criteria for Grading Myelofibrosis, (Thiele et al., 2005). - Life expectancy > 36 weeks. - Able to swallow capsules. - Amenable to spleen size determination, bone marrow evaluations, and peripheral blood sampling during the study. - Must have discontinued ET therapy at least 2 weeks (4 weeks for interferon) prior to study drug initiation. - Agrees to use an approved method of contraception from Screening until 28 days after last administration of the study drug. Acceptable methods of birth control include: birth control pills, depo-progesterone injections, a vaginal hormonal contraceptive ring, a barrier contraceptive such as a condom with spermicide cream or gel, diaphragms or cervical cap with spermicide cream or gel, or an intrauterine device (IUD). - If male, agrees not to donate sperm or father a child for at least one month after the last dose of the study medication. Exclusion Criteria: - Greater than 3 separate transfusion episodes over the last 6 months and/or any transfusion over the last 4 weeks. - Eastern Cooperative Oncology Group (ECOG) questionnaire score of 3 or greater. - Currently pregnant or planning on being pregnant in the following 6 months or currently breastfeeding. - Currently residing outside the United States. - History of splenectomy. - Unresolved treatment related toxicities from prior therapies (unless resolved to = Grade 1). - Uncontrolled active infection. - Known positive for HIV or infectious hepatitis, type A, B or C. - Current use of monoamine oxidase A and B inhibitors (MAOIs). - Evidence at the time of screening of increased risk of bleeding, including any of the following: 1. Activated partial thromboplastin time (aPTT) > 1.3 x the upper limit of normal 2. International normalized ratio (INR) >1.3 x the local upper limit of normal 3. Known Acquired Von Willebrand's disorder.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
IMG-7289
Single starting dose with individualized dose titrations throughout

Locations

Country Name City State
United States Mays Cancer Center San Antonio Texas

Sponsors (2)

Lead Sponsor Collaborator
The University of Texas Health Science Center at San Antonio Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary The proportion of patients who achieve complete hematologic remission 24 weeks using ELN (European Leukemia Net) criteria for ET (essential thrombocythemia)
See also
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Recruiting NCT01816022 - Myeloproliferative Neoplasms and Bone Structure N/A
Active, not recruiting NCT05223920 - Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-7289-CTP-202/MK-3543-005) Phase 2
Terminated NCT00522574 - A Safety Study of XL019 in Adults With Myelofibrosis Phase 1
Completed NCT01134120 - A Study in Myeloproliferative Disorders Phase 1