Thoracic Cancer Clinical Trial
Official title:
Early Imaging Biomarkers to Predict Radiation-Induced Cardiopulmonary Toxicity in Patients With Thoracic Malignancies
The purpose of this study is to investigate if cardiac MRI, blood biomarkers, and lung CT scans can detect early changes to the associated with radiation therapy in patients receiving radiation treatment for thoracic cancer.
This study seeks to investigate the utility of novel imaging biomarkers, namely whole lung
volumetric CT scans and cardiac MRI, to non-invasively identify early pathologic changes in
pulmonary and cardiac function resulting from thoracic radiation. The ability to identify
these changes during the course of treatment offers a powerful tool to optimize radiation
dose distributions within uninvolved normal tissue by adapting treatment to the individual
patient response. In addition it may lead to other therapeutic interventions designed to
reduce long term cardiopulmonary toxicity.
The cardiac MRI will be performed using Aminophylline, Gadopentetate Dimeglumine and
Regadenoson. These are not FDA approved for this purpose, but are being used off label and
are IND exempt. Additionally, patients will be consented with an optional choice to retain
research blood samples for 15 years after the completion of the study. This will allow
cutting edge analysis for biomarkers that may be discovered in the future.
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