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Effects of Glucagon Like Peptide 1 (GLP-1) Analogues on Fluid Intake — GATE  

Thirst Clinical Trial

Official title:
Effects of GLP-1 Analogues on Fluid Intake in Healthy Volunteers - "The GATE-Study"

Clinical Trial Summary

The aim of this study is to elucidate whether GLP-1 analogues influence not only appetite but also thirst perception. It is hypothesized that GLP-1 analogues reduce fluid intake in healthy volunteers compared to Placebo.

Clinical Trial Description

GLP-1 analogues are well known to stimulate glucose-induced insulin secretion and to reduce energy intake. Recent findings from animal and human studies suggest a role of GLP-1 in regulating water and salt homeostasis. GLP-1 has been shown to reduce fluid intake after an oral salt load or during a meal - pointing to a hypodipsic effect. The aim of this study is to elucidate whether these putative hypodipsic properties of GLP-1 analogues reduce fluid intake in healthy volunteers compared to placebo assessed during an evaluation visit of 8 hours. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03141632
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase Phase 2
Start date October 17, 2016
Completion date May 12, 2017
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