Thermal Injury Clinical Trial
— Caspo-brûlésOfficial title:
Pharmacokinetics of Caspofungin in Burn Patients
Verified date | July 2011 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Interventional |
Drug pharmacokinetics of antimicrobial agents is significantly altered in the burn patients. Additionally, burn patient population exhibits a wide inter- and intrapatient variation in drug handling. Several investigations carried out in burn patients treated with e.g. fluconazole showed the requirement to increase daily dose in comparison with healthy volunteers. However, no pharmacokinetic data are available of caspofungin in the burn population. The aim of this investigation is to investigate pharmacokinetics of caspofungin in burn patients after a single usual dose (70 mg i.v.), in order to determine the optimal dose in this population.
Status | Completed |
Enrollment | 2 |
Est. completion date | December 2010 |
Est. primary completion date | February 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - 18 - 60 years old - burn surface : 20-60% total body surface area - delay of injury time : 8-15 days - lack of fungal infection - delay of hospitalization : > 5 days - written informed consent - last biological picture in 24 hours before inclusion Exclusion Criteria: - survival inferior to 5 days - surgical intervention planned in the next five days following inclusion - moderate or severe hepatic impairment according to Child Plug B > 9 - pregnancy - allergy to caspofungin or excipients (saccharose, mannitol and frozen acetic acid) - patient already included in other study - concomitant administration of CYP450 inducers : rifampicin, efavirenz, phenobarbital, phenytoin, carbamazepine - withdrawal of consent - event (during the first 48 hours following administration) susceptible to modify pharmacokinetic parameters - Investigator decision - no social security insurance |
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | Cochin | Paris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | area under the curve of caspofungin plasma concentrations over 24 hours mean peak level and trough concentration (24 hours after dosing) | 18 months | Yes | |
Secondary | mean total clearance | 18 months | Yes | |
Secondary | mean distribution volume | 12 months | Yes |
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