Thalassemia Clinical Trial
Official title:
Renal Function Among Thalassemia Patients Treated by a Oral Chelator Deferasirox
Thalassemia Major patients developed Iron Overload due to blood transfusions and intestinal iron absorption. Renal function caused by Iron overload was studied in a previous study and shows principally tubular disfunction. In this previous study the Iron chelator used was Deferrioxamine. In the last five years an oral Iron chelator was introduced and approved by the FDA, Deferasirox, (Novartis, Switzerland and USA). The purpose of this study is to assess the renal function in Thalassemia Major patients treated with this new oral iron chelator and compare the results with our previous study.
Patients with Thalassemia Major. The laboratory tests that will be studied are: Urine dip
stick, Urea, Creatinine, Na, K, Uric Acid, Calcium, Phosphorus in serum and urine, and N
acetyl-b-D-glucosaminidase in Urine.Blood gases will be also taken in serum samples.
The overall iron accumulation will also be calculated based in the amount of Packed Cells
Units transfused. The total iron burden will also assessed by measurement of Transferrin
saturation and Serum Ferritin.
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Observational Model: Cohort, Time Perspective: Retrospective
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