Tetraplegia Clinical Trial
Official title:
Spinal Cord Stimulation for Reanimation After Nervous System Injury
Restoring upper extremity function in patients with cervical spinal cord injury is extremely important for patients' independence and quality of life. At present, there are limited options for hand or arm reanimation in this patient population. Nerve transfer is one such option that can partially restore the natural movement of hand or arm function in select patients. The investigators are interested in understanding whether recovery of hand or arm motor function after nerve transfer can be augmented by cervical epidural spinal cord stimulation.
The study will enroll up to 20 participants in a single arm prospective clinical study. Potential participants will have already had a nerve transfer surgery more than 6 months prior to enrollment and will have also completed post-nerve transfer physical /occupational neurorehabilitation. At baseline, upper extremity muscle strength, muscle force and nerve health with needle electromyography and neuroimaging will be tested. Patients will undergo percutaneous (temporary) spinal cord stimulator leads placement in the cervical supralesional spine region. Week 0-4: Weekly testing of motor function and muscle contraction force with the stimulation turned on versus turned off will be performed. Stimulation parameters for each target upper extremity muscle will also be documented. Temporary leads will be removed after approximately 4 weeks. At the last research visit at approximately 6-7 weeks post leads placement muscle strength/force will be assessed to determine the duration of the stimulation effect (if it is sustained). To assess any improvement of nerve health, neuroimaging and electromyography will also be performed. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04736849 -
Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury
|
N/A | |
Terminated |
NCT03513783 -
Elbow Extension Restoration Surgery in People With Tetraplegia: Evolution of the Muscular Co-activations of the Upper Limb During the Post-operative Rehabilitation
|
N/A | |
Recruiting |
NCT05432999 -
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
|
N/A | |
Completed |
NCT03698136 -
Electrical Stimulation in Denervated Muscles of the Upper Limbs
|
N/A | |
Recruiting |
NCT05553457 -
MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury
|
N/A | |
Completed |
NCT04020770 -
Influence of Upper Extremity Vibration on Spasticity and Function in Persons With Tetraplegia
|
N/A | |
Completed |
NCT04964635 -
TETRAGRIP II - Usability Trial of an FES Orthosis for People With Tetraplegia.
|
N/A | |
Recruiting |
NCT06094205 -
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
|
N/A | |
Enrolling by invitation |
NCT02602639 -
Functional Electrical Stimulation With Rowing as Exercise After Spinal Cord Injury
|
N/A | |
Completed |
NCT01467856 -
Sleep Disordered Breathing
|
N/A | |
Completed |
NCT00385918 -
Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)
|
N/A | |
Recruiting |
NCT05724173 -
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
|
N/A | |
Completed |
NCT05555914 -
Neural Stimulation for Hand Grasp in People With Tetraplegia
|
N/A | |
Completed |
NCT03975075 -
Biofeedback Treatment of Anxiety Associated With Chronic Spinal Cord Injury
|
N/A | |
Recruiting |
NCT01474148 -
A Neuroprosthesis for Seated Posture and Balance
|
N/A | |
Active, not recruiting |
NCT03811301 -
[BrainConnexion] - Neurodevice Phase I Trial
|
N/A | |
Terminated |
NCT01498991 -
Spinal Cord Injury Leg Rehabilitation
|
Phase 1/Phase 2 | |
Completed |
NCT03237091 -
Enhancing Corticospinal Excitability to Improve Functional Recovery
|
N/A | |
Recruiting |
NCT05665998 -
Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation
|
N/A | |
Completed |
NCT01393444 -
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
|
N/A |