Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Tetraplegia C5-C6 Clinical Trial

Official title:

Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02860403
• Other study ID #: 2008-541
• Status: Completed
• Phase: N/A
• Start date: February 2013
• Est. completion date: March 2013

Study information

• Verified date: August 2016
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: March 2013
• Est. primary completion date: March 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• 18-55 years old,

• quadriplegia elicited by spinal cord injury (SCI) at the C5, C5-C6, C6, or C6-C7 level,

• complete infra-lesional motor deficit according to the ASIA impairment scale with finger and forearm flexor muscles paralysis,

• post-traumatic period >6 months (since a motor recovery plateau is usually reached at 6-month post-SCI

Exclusion Criteria:

• non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension),

• cerebral damage and/or cognitive deficit,

• elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy,

• participation to another study

• presence of metallic objects within the body incompatible with MEG or functional magnetic resonance imaging (fMRI) recordings.

Related Conditions & MeSH terms

• Quadriplegia
• Tetraplegia C5-C6
• Tetraplegia C6-C7

Intervention

Procedure:
• motor imagery
Intervention consisted of supervised MI during which the participants were trained to imagine performing a single-joint wrist extension movement and a multiple-joint reach-to-grasp movement using tenodesis. The two movements were practiced in separate blocks and each 45 minute MI session consisted of six to eight blocks. Within a given block patients; i) performed the movement once, ii) imagined it using visual imagery (between five and ten repetitions), iii) performed the movement again, and iv) imagined it using kinesthetic imagery (between five and ten repetitions). All movements (performed and imagined) were timed by the experimenter to ensure that the durations of both imagined and physically practiced movements were similar. Imagery vividness was controlled with self-rated assessments using a visual analogic scale (from 0, the image or feeling was absent, to 10 when it was as clear or intense as physical practice).

Locations

Country	Name	City	State
France	Hôpital Henry Gabrielle - Médecine physique et Réadaptation, Hospices Civils de Lyon, 20 Route de Vourles,	Saint-Genis-Laval

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

References & Publications (1)

Mateo S, Reilly KT, Collet C, Rode G. Descriptive pilot study of vividness and temporal equivalence during motor imagery training after quadriplegia. Ann Phys Rehabil Med. 2018 Sep;61(5):300-308. doi: 10.1016/j.rehab.2018.06.003. Epub 2018 Jun 23. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Motor imagery ability	Motor imagery ability assessed by magnetoencephalography measurements	10 weeks
Secondary	Movement time (MT)	Kinematic parameters of movement: temporal parameters: movement time (MT)	10 weeks
Secondary	absolute time to peak velocity	Kinematic parameters of movement: temporal parameters: absolute time to peak velocity	10 weeks
Secondary	movement amplitude at peak velocity	Kinematic parameters of movement: temporal parameters: movement amplitude at peak velocity	10 weeks
Secondary	time to opening	Kinematic parameters of movement: temporal parameters: time to opening	10 weeks
Secondary	time to maximal opening	Kinematic parameters of movement: temporal parameters: time to maximal opening	10 weeks
Secondary	amplitude of maximal opening	Kinematic parameters of movement: temporal parameters: amplitude of maximal opening	10 weeks
Secondary	Trajectory of movement measured in the XY plane	Kinematic parameters of movement: spatial parameters: Trajectory of movement measured in the XY plane	10 weeks
Secondary	height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane	Kinematic parameters of movement: spatial parameters: height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane	10 weeks
Secondary	muscular force evaluated by muscle testing performed by a physiotherapist	muscular force evaluated by muscle testing performed by a physiotherapist (score from 0 to 5)	10 weeks
Secondary	joint amplitude evaluated in degrees (°) by the physiotherapist		10 weeks
Secondary	Box and Block test	Box and Block test performed by an occupational therapist	10 weeks
Secondary	Minnesota test.	Minnesota test performed by an occupational therapist	10 weeks
Secondary	amplitude of electrodermal responses	mental chronometric assessment associated with acquisition of electrodermal responses	10 weeks
Secondary	duration of electrodermal responses	mental chronometric assessment associated with acquisition of electrodermal responses	10 weeks
Secondary	Kinesthetic and Visual Imagery Questionnaire	The Kinesthetic and Visual Imagery Questionnaire (KVIQ) will allow a qualitative evaluation of the mental representation capacity of patients	10 weeks