Tetralogy of Fallot Clinical Trial
Official title:
Reoxygenation Cardiopulmonary Bypass for Surgical Repair of Pediatric Cyanotic CHD
Evidence is emerging that those patients with cyanotic pathologies may be more vulnerable to
end-organ injury during and after surgery than those patients without, because of compromised
cardiopulmonary performances or the proinflammatory state that follows conventional hyperoxic
cardiopulmonary bypass.
Several clinical and basic studies have identified that controlled oxygenation during the
initiation of bypass significantly improved the cardiac adaptation and remodeling capacity
than hyperoxic oxygenation strategy among cyanotic patients undergoing tetralogy of Fallot
repair, as evidenced by these reduced myocardial gene expression profiles associated with
reoxygenation injury.
The investigators designed the reoxygenation for pediatric cardiac surgery study to
investigate the effect of reoxygenation during cardiopulmonary bypass on clinical outcomes in
patients with cyanotic congenital heart disease .
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