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Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study

Testicular Cancer Clinical Trial

Official title:
Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study

Clinical Trial Summary

Cisplatin-combination chemotherapy causes inevitably DNA damage by platinum-DNA adduct formation of both tumor cells but also healthy cells. It therefore stands to reason that testicular cancer treatment causes an increased burden of senescent cells, which causes upregulation of the SASP resulting in a pro-inflammatory phenotype. The investigators hypothesize that this may be an important mechanism behind development of late effects and an early ageing phenotype after treatment for testicular cancer.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04113122
Study type Interventional
Source University Medical Center Groningen
Contact J. A. Gietema, prof.
Phone +31 50 361 2821
Email j.a.gietema@umcg.nl
Status Recruiting
Phase N/A
Start date February 9, 2019
Completion date September 2024
View Details
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