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Comparison of Tofacitinib and Prednisolone in the Treatment of Active Takayasu's Arteritis — TOFGCTAK  

Takayasu Arteritis Clinical Trial

Official title:
A Prospective Randomized Double-blinded Controlled Single Center Clinical Study of the Efficacy and Safety for Tofacitinib Compared With Glucocorticoid in the Remission-reduction Treatment of Active Takayasu's Arteritis

Clinical Trial Summary

This is a prospective, double-blinded, single center, randomized clinical trial. It compares the clinical efficacy and safety of thees 2 drugs in the treatment of active Takayasu's arteritis patients.

Clinical Trial Description

In this study, 40 Takayasu's arteritis patients with active disease will be enrolled. Patients are randomized into the tofacitinib treatment group and prednisolone treatment group. Patients will follow the same reduction steps for prednisolone and its placebo. The primary end point is the percentage of patients who are in complete response at week 24. The efficacy will be evaluated at week 4, 12 and 24. Safety is also monitored during the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05749666
Study type Interventional
Source Chinese SLE Treatment And Research Group
Contact Xinping Tian, MD
Phone +86-13691165939
Email tianxp6@126.com
Status Recruiting
Phase Phase 3
Start date January 20, 2023
Completion date July 20, 2025
View Details
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